PDB entry 2vgp
View 2vgp on RCSB PDB site
Description: crystal structure of aurora b kinase in complex with a aminothiazole inhibitor
Class: transferase
Keywords: nucleotide-binding, serine/threonine-protein kinase, ATP-binding, transferase, coiled coil, cell division, kinase, cancer, incenp, nucleus, mitosis, aurora b, metal-binding, aminothiazole, phosphorylation, magnesium, cell cycle, centromere, microtubule
Deposited on
2007-11-15, released
2008-02-26
The last revision prior to the SCOPe 2.05 freeze date was dated
2009-02-24, with a file datestamp of
2009-03-01.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: 0.208
AEROSPACI score: 0.52
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: serine/threonine-protein kinase 12-a
Species: Xenopus laevis [TaxId:8355]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d2vgpa_ - Chain 'B':
Compound: serine/threonine-protein kinase 12-a
Species: Xenopus laevis [TaxId:8355]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d2vgpb_ - Chain 'C':
Compound: inner centromere protein a
Species: Xenopus laevis [TaxId:8355]
Database cross-references and differences (RAF-indexed):
- Chain 'D':
Compound: inner centromere protein a
Species: Xenopus laevis [TaxId:8355]
Database cross-references and differences (RAF-indexed):
- Heterogens: AD6, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2vgpA (A:)
talaempkrkftiddfdigrplgkgkfgnvylarekqnkfimalkvlfksqlekegvehq
lrreieiqshlrhpnilrmynyfhdrkriylmlefaprgelykelqkhgrfdeqrsatfm
eeladalhycherkvihrdikpenllmgykgelkiadfgwsvhapslrrrtmcgtldylp
pemiegkthdekvdlwcagvlcyeflvgmppfdspshtethrrivnvdlkfppflsdgsk
dliskllryhppqrlplkgvmehpwvkansrrvlppvyqstqsk
Sequence, based on observed residues (ATOM records): (download)
>2vgpA (A:)
ftiddfdigrplgkgnvylarekqnkfimalkvlfksqlekegvehqlrreieiqshlrh
pnilrmynyfhdrkriylmlefaprgelykelqkhgrfdeqrsatfmeeladalhycher
kvihrdikpenllmgykgelkiadfgwsvhapslrrrtmcgtldylppemiegkthdekv
dlwcagvlcyeflvgmppfdspshtethrrivnvdlkfppflsdgskdliskllryhppq
rlplkgvmehpwvkansrrvlppvyq
- Chain 'B':
Sequence, based on SEQRES records: (download)
>2vgpB (B:)
talaempkrkftiddfdigrplgkgkfgnvylarekqnkfimalkvlfksqlekegvehq
lrreieiqshlrhpnilrmynyfhdrkriylmlefaprgelykelqkhgrfdeqrsatfm
eeladalhycherkvihrdikpenllmgykgelkiadfgwsvhapslrrrtmcgtldylp
pemiegkthdekvdlwcagvlcyeflvgmppfdspshtethrrivnvdlkfppflsdgsk
dliskllryhppqrlplkgvmehpwvkansrrvlppvyqstqsk
Sequence, based on observed residues (ATOM records): (download)
>2vgpB (B:)
talaempkrkftiddfdigrplgkgkfgnvylarekqnkfimalkvlfksqlekegvehq
lrreieiqshlrhpnilrmynyfhdrkriylmlefaprgelykelqkhgrfdeqrsatfm
eeladalhycherkvihrdikpenllmgykgelkiadfgwsvhapslrrrtmcgtldylp
pemiegkthdekvdlwcagvlcyeflvgmppfdspshtethrrivnvdlkfppflsdgsk
dliskllryhppqrlplkgvmehpwvkansrrvlppvy
- Chain 'C':
No sequence available.
- Chain 'D':
No sequence available.