PDB entry 2vgg

View 2vgg on RCSB PDB site
Description: human erythrocyte pyruvate kinase: r479h mutant
Class: transferase
Keywords: metal-binding, phosphorylation, pyruvate kinase in the active r-state, kinase, pyruvate, magnesium, glycolysis, transferase, disease mutation
Deposited on 2007-11-13, released 2007-11-20
The last revision prior to the SCOPe 2.03 freeze date was dated 2011-12-07, with a file datestamp of 2011-12-02.
Experiment type: XRAY
Resolution: 2.74 Å
R-factor: 0.254
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: pyruvate kinase isozymes r/l
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30613
      • engineered mutation (432)
    Domains in SCOPe 2.03: d2vgga1, d2vgga2, d2vgga3
  • Chain 'B':
    Compound: pyruvate kinase isozymes r/l
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30613
      • engineered mutation (432)
    Domains in SCOPe 2.03: d2vggb1, d2vggb2, d2vggb3
  • Chain 'C':
    Compound: pyruvate kinase isozymes r/l
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30613
      • engineered mutation (432)
    Domains in SCOPe 2.03: d2vggc1, d2vggc2, d2vggc3
  • Chain 'D':
    Compound: pyruvate kinase isozymes r/l
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30613
      • engineered mutation (432)
    Domains in SCOPe 2.03: d2vggd1, d2vggd2, d2vggd3
  • Heterogens: FBP, PGA, K, MN

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2vggA (A:)
ltqelgtaffqqqqlpaamadtflehlclldidsepvaarstsiiatigpasrsverlke
mikagmniarlnfshgsheyhaesianvreavesfagsplsyrpvaialdtkgpeirtgi
lqggpesevelvkgsqvlvtvdpafrtrgnantvwvdypnivrvvpvggriyiddglisl
vvqkigpeglvtqvenggvlgsrkgvnlpgaqvdlpglseqdvrdlrfgvehgvdivfas
fvrkasdvaavraalgpeghgikiiskienhegvkrfdeilevsdgimvargdlgieipa
ekvflaqkmmigrcnlagkpvvcatqmlesmitkprptraetsdvanavldgadcimlsg
etakgnfpveavkmqhaiareaeaavyhrqlfeelrraaplsrdptevtaigaveaafkc
caaaiivltttghsaqllsryrpraaviavtrsaqaarqvhlcrgvfpllyreppeaiwa
ddvdrrvqfgiesgklrgflrvgdlvivvtgwrpgsgytnimrvlsis

    Sequence, based on observed residues (ATOM records): (download) 
    >2vggA (A:)
amadtflehlclldidsepvaarstsiiatigpasrsverlkemikagmniarlnfshgs
heyhaesianvreavesfagsplsyrpvaialdtkgpeirtgilqggpesevelvkgsqv
lvtvdpafrtrgnantvwvdypnivrvvpvggriyiddglislvvqeglvtqvenggvlg
srkgvnlpgaqvdlpglseqdvrdlrfgvehgvdivfasfvrkasdvaavraalgpeghg
ikiiskienhegvkrfdeilevsdgimvargdlgieipaekvflaqkmmigrcnlagkpv
vcatqmlesmitkprptraetsdvanavldgadcimlsgetakgnfpveavkmqhaiare
aeaavyhrqlfeelrraaplsrdptevtaigaveaafkccaaaiivltttghsaqllsry
rpraaviavtrsaqaarqvhlcrgvfpllyreppeaiwaddvdrrvqfgiesgklrgflr
vgdlvivvtgwrpgsgytnimrvlsi

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2vggB (B:)
ltqelgtaffqqqqlpaamadtflehlclldidsepvaarstsiiatigpasrsverlke
mikagmniarlnfshgsheyhaesianvreavesfagsplsyrpvaialdtkgpeirtgi
lqggpesevelvkgsqvlvtvdpafrtrgnantvwvdypnivrvvpvggriyiddglisl
vvqkigpeglvtqvenggvlgsrkgvnlpgaqvdlpglseqdvrdlrfgvehgvdivfas
fvrkasdvaavraalgpeghgikiiskienhegvkrfdeilevsdgimvargdlgieipa
ekvflaqkmmigrcnlagkpvvcatqmlesmitkprptraetsdvanavldgadcimlsg
etakgnfpveavkmqhaiareaeaavyhrqlfeelrraaplsrdptevtaigaveaafkc
caaaiivltttghsaqllsryrpraaviavtrsaqaarqvhlcrgvfpllyreppeaiwa
ddvdrrvqfgiesgklrgflrvgdlvivvtgwrpgsgytnimrvlsis

    Sequence, based on observed residues (ATOM records): (download) 
    >2vggB (B:)
qqqqlpadtflehlclldidsepvaarstsiiatigpasrsverlkemikagmniarlnf
shgsheyhaesianvreavesfagsplsyrpvaialdtkgpeirtivelvkgsqvlvtan
tvwvdypnivrvvpvggriyiddglislvvvenggvlgsrkgvnlpgaqdlpglseqdvr
dlrfgvehgvdivfasfvrkasdvaavraalgpeghgikiiskienhegvkrfdeilevs
dgimvargdlgieipaekvflaqkmmigrcnlagkpvvcatqmlesmitkprptraetsd
vanavldgadcimlsgetakgnfpveavkmqhaiareaeaavyhrqlfeelrraaplsrd
ptevtaigaveaafkccaaaiivltttghsaqllsryrpraaviavtrsaqaarqvhlcr
gvfpllyreppeaiwaddvdrrvqfgiesgklrgflrvgdlvivvtgwrpgsgytnimrv
lsi

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2vggC (C:)
ltqelgtaffqqqqlpaamadtflehlclldidsepvaarstsiiatigpasrsverlke
mikagmniarlnfshgsheyhaesianvreavesfagsplsyrpvaialdtkgpeirtgi
lqggpesevelvkgsqvlvtvdpafrtrgnantvwvdypnivrvvpvggriyiddglisl
vvqkigpeglvtqvenggvlgsrkgvnlpgaqvdlpglseqdvrdlrfgvehgvdivfas
fvrkasdvaavraalgpeghgikiiskienhegvkrfdeilevsdgimvargdlgieipa
ekvflaqkmmigrcnlagkpvvcatqmlesmitkprptraetsdvanavldgadcimlsg
etakgnfpveavkmqhaiareaeaavyhrqlfeelrraaplsrdptevtaigaveaafkc
caaaiivltttghsaqllsryrpraaviavtrsaqaarqvhlcrgvfpllyreppeaiwa
ddvdrrvqfgiesgklrgflrvgdlvivvtgwrpgsgytnimrvlsis

    Sequence, based on observed residues (ATOM records): (download) 
    >2vggC (C:)
qqqlpaadtflehlclldidsepvaarstsiiatigpasrsverlkemikagmniarlnf
shgsheyhaesianvreavesfagsplsyrpvaialdtkgpeirtgilqggpesevelvk
gsqvlvtvdpafrtrgnantvwvdypnivrvvpvggriyiddglislvvqkigpeglvtq
venggvlgsrkgvnlpgaqvdlpglseqdvrdlrfgvehgvdivfasfvrkasdvaavra
algpeghgikiiskienhegvkrfdeilevsdgimvargdlgieipaekvflaqkmmigr
cnlagkpvvcatqmlesmitkprptraetsdvanavldgadcimlsgetakgnfpveavk
mqhaiareaeaavyhrqlfeelrraaplsrdptevtaigaveaafkccaaaiivltttgh
saqllsryrpraaviavtrsaqaarqvhlcrgvfpllyreppeaiwaddvdrrvqfgies
gklrgflrvgdlvivvtgwrpgsgytnimrvlsi

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2vggD (D:)
ltqelgtaffqqqqlpaamadtflehlclldidsepvaarstsiiatigpasrsverlke
mikagmniarlnfshgsheyhaesianvreavesfagsplsyrpvaialdtkgpeirtgi
lqggpesevelvkgsqvlvtvdpafrtrgnantvwvdypnivrvvpvggriyiddglisl
vvqkigpeglvtqvenggvlgsrkgvnlpgaqvdlpglseqdvrdlrfgvehgvdivfas
fvrkasdvaavraalgpeghgikiiskienhegvkrfdeilevsdgimvargdlgieipa
ekvflaqkmmigrcnlagkpvvcatqmlesmitkprptraetsdvanavldgadcimlsg
etakgnfpveavkmqhaiareaeaavyhrqlfeelrraaplsrdptevtaigaveaafkc
caaaiivltttghsaqllsryrpraaviavtrsaqaarqvhlcrgvfpllyreppeaiwa
ddvdrrvqfgiesgklrgflrvgdlvivvtgwrpgsgytnimrvlsis

    Sequence, based on observed residues (ATOM records): (download) 
    >2vggD (D:)
paatflehlcllidsepvaarstsiiatigpasrsverlkemikagmniarlnfshgshe
yhaesianvreavesfagsplsyrpvaialdtkgpeirtgilesevelvkgsqlvtvdpa
frtrgnantvwvdypnivrvvpvggriyiddglislvvqkipelvtqvenggvlgsrkgv
nlpgaqvdlpglseqdvrdlrfgvehgvdivfasfvrkasdvaavraalgpeghgikiis
kienhegvkrfdeilevsdgimvargdlgieipaekvflaqkmmigrcnlagkpvvcatq
mlesmitkprptraetsdvanavldgadcimlsgetakgnfpveavkmqhaiareaeaav
yhrqlfeelrraaplsrdptevtaigaveaafkccaaaiivltttghsaqllsryrpraa
viavtrsaqaarqvhlcrgvfpllyreppeaiwaddvdrrvqfgiesgklrgflrvgdlv
ivvtgwrpgsgytnimrvlsi