PDB entry 2vfe

View 2vfe on RCSB PDB site
Description: crystal structure of f96s mutant of plasmodium falciparum triosephosphate isomerase with 3-phosphoglycerate bound at the dimer interface
Class: isomerase
Keywords: 3-phosphoglycerate, plasmodium falciparum, isomerase, glycolysis, pentose shunt, gluconeogenesis, lipid synthesis, dimer interface, fatty acid biosynthesis, triosephosphate isomerase
Deposited on 2007-11-03, released 2008-12-09
The last revision prior to the SCOPe 2.04 freeze date was dated 2009-08-04, with a file datestamp of 2009-07-31.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.22115
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: triosephosphate isomerase
    Species: PLASMODIUM FALCIPARUM [TaxId:5833]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q07412 (Start-247)
      • engineered mutation (95)
      • engineered mutation (162)
    Domains in SCOPe 2.04: d2vfea_
  • Chain 'B':
    Compound: triosephosphate isomerase
    Species: PLASMODIUM FALCIPARUM [TaxId:5833]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q07412 (Start-247)
      • engineered mutation (95)
      • engineered mutation (162)
    Domains in SCOPe 2.04: d2vfeb_
  • Heterogens: 3PG, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2vfeA (A:)
markyfvaanwkcngtlesiksltnsfnnldfdpskldvvvfpvsvhydhtrkllqskfs
tgiqnvskfgngsytgevsaeiakdlnieyviighserrkyfhetdedvreklqaslknn
lkavvcfgesleqreqnktievitkqvkafvdlidnfdnvilvyeplwaigtgktatpeq
aqlvhkeirkivkdtcgekqanqirilyggsvntencssliqqedidgflvgnaslkesf
vdiiksam

    Sequence, based on observed residues (ATOM records): (download) 
    >2vfeA (A:)
arkyfvaanwkcngtlesiksltnsfnnldfdpskldvvvfpvsvhydhtrkllqskfst
giqnvskfgngsytgevsaeiakdlnieyviighserrkyfhetdedvreklqaslknnl
kavvcfgesleqreqnktievitkqvkafvdlidnfdnvilvyeplwaigtgktatpeqa
qlvhkeirkivkdtcgekqanqirilyggsvntencssliqqedidgflvgnaslkesfv
diiksam

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2vfeB (B:)
markyfvaanwkcngtlesiksltnsfnnldfdpskldvvvfpvsvhydhtrkllqskfs
tgiqnvskfgngsytgevsaeiakdlnieyviighserrkyfhetdedvreklqaslknn
lkavvcfgesleqreqnktievitkqvkafvdlidnfdnvilvyeplwaigtgktatpeq
aqlvhkeirkivkdtcgekqanqirilyggsvntencssliqqedidgflvgnaslkesf
vdiiksam

    Sequence, based on observed residues (ATOM records): (download) 
    >2vfeB (B:)
rkyfvaanwkcngtlesiksltnsfnnldfdpskldvvvfpvsvhydhtrkllqskfstg
iqnvskfgngsytgevsaeiakdlnieyviighserrkyfhetdedvreklqaslknnlk
avvcfgesleqreqnktievitkqvkafvdlidnfdnvilvyeplwaigtgktatpeqaq
lvhkeirkivkdtcgekqanqirilyggsvntencssliqqedidgflvgnaslkesfvd
iiksam