PDB entry 2vfa

View 2vfa on RCSB PDB site
Description: Crystal structure of a chimera of Plasmodium falciparum and human hypoxanthine-guanine phosphoribosyl transferases
Class: transferase
Keywords: hypoxanthine-guanine phosphoribosyl transferase (hgprt), purine salvage, disease mutation, glycosyltransferase, transferase, metal-binding, gout, chimera, magnesium
Deposited on 2007-11-02, released 2008-06-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-07-05, with a file datestamp of 2017-06-30.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine-guanine phosphoribosyltransferase
    Species: Plasmodium falciparum [TaxId:5833]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2vfaa_
  • Chain 'B':
    Compound: hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine-guanine phosphoribosyltransferase
    Species: Plasmodium falciparum [TaxId:5833]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2vfab_
  • Heterogens: 5GP, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2vfaA (A:)
mpipnnpgagenafdpvfvkdddgydldsfmipahykkyltkvlvpngviknrieklard
vmkemgghhivalcvlkggykffadlldyikalnrnsdrsipmtvdfirlksycndqstg
dikviggddlstltgknvlivediidtgktmqtllslvrqynpkmvkvaclfikrtplwn
gfkadfvgfsipdhfvvgysldyneifrdldhcclvndegkkkykatsl

    Sequence, based on observed residues (ATOM records): (download) 
    >2vfaA (A:)
dpvfvkdddgydldsfmipahykkyltkvlvpngviknrieklardvmkemgghhivalc
vlkggykffadlldyikalnrnsdrsipmtvdfirkviggddlstltgknvlivediidt
gktmqtllslvrqynpkmvkvaclfikrtplwngfkadfvgfsipdhfvvgysldyneif
rdldhcclvndegkkk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2vfaB (B:)
mpipnnpgagenafdpvfvkdddgydldsfmipahykkyltkvlvpngviknrieklard
vmkemgghhivalcvlkggykffadlldyikalnrnsdrsipmtvdfirlksycndqstg
dikviggddlstltgknvlivediidtgktmqtllslvrqynpkmvkvaclfikrtplwn
gfkadfvgfsipdhfvvgysldyneifrdldhcclvndegkkkykatsl

    Sequence, based on observed residues (ATOM records): (download) 
    >2vfaB (B:)
afdpvfvkdddgydldsfmipahykkyltkvlvpngviknrieklardvmkemgghhiva
lcvlkggykffadlldyikalnrnsdrsipmtvdfirlkdikviggddlstltgknvliv
ediidtgktmqtllslvrqynpkmvkvaclfikrtplwngfkadfvgfsipdhfvvgysl
dyneifrdldhcclvndegkkkyka