PDB entry 2vf0

View 2vf0 on RCSB PDB site
Description: crystal structure of the thymidylate synthase k48q complexed with 5no2dump and bw1843u89
Class: transferase
Keywords: nucleotide biosynthesis, substrate anologue, antifolate binding, RNA-binding, transferase, methyltransferase, repressor, bw1843u89, cytoplasm, 5-no2-dump, thymidylate synthase, translation regulation
Deposited on 2007-10-27, released 2007-12-04
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-07-12, with a file datestamp of 2017-07-07.
Experiment type: XRAY
Resolution: 3 Å
R-factor: N/A
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thymidylate synthase
    Species: ESCHERICHIA COLI [TaxId:511693]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0A884 (0-263)
      • engineered mutation (47)
    Domains in SCOPe 2.08: d2vf0a_
  • Chain 'B':
    Compound: Thymidylate synthase
    Species: ESCHERICHIA COLI [TaxId:511693]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0A884 (0-263)
      • engineered mutation (47)
    Domains in SCOPe 2.08: d2vf0b_
  • Heterogens: NDU, F89, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2vf0A (A:)
mkqylelmqkvldegtqkndrtgtgtlsifghqmrfnlqdgfplvttqrchlrsiihell
wflqgdtniaylhennvtiwdewadengdlgpvygkqwrawptpdgrhidqittvlnqlk
ndpdsrriivsawnvgeldkmalapchaffqfyvadgklscqlyqrscdvflglpfnias
yallvhmmaqqcdlevgdfvwtggdthlysnhmdqthlqlsreprplpkliikrkpesif
dyrfedfeiegydphpgikapvai

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2vf0B (B:)
mkqylelmqkvldegtqkndrtgtgtlsifghqmrfnlqdgfplvttqrchlrsiihell
wflqgdtniaylhennvtiwdewadengdlgpvygkqwrawptpdgrhidqittvlnqlk
ndpdsrriivsawnvgeldkmalapchaffqfyvadgklscqlyqrscdvflglpfnias
yallvhmmaqqcdlevgdfvwtggdthlysnhmdqthlqlsreprplpkliikrkpesif
dyrfedfeiegydphpgikapvai