PDB entry 2vem
View 2vem on RCSB PDB site
Description: Structure-based enzyme engineering efforts with an inactive monomeric TIM variant: the importance of a single point mutation for generating an active site with suitable binding properties
Class: isomerase
Keywords: isomerase, triosephosphate isomerase, tim barrel, glycolysis, engineering, pentose shunt, binding pocket, gluconeogenesis, lipid synthesis, substrate specificity, fatty acid biosynthesis, tim, enzyme, monomeric, glycosome
Deposited on
2007-10-25, released
2008-02-19
The last revision prior to the SCOPe 2.08 freeze date was dated
2019-07-24, with a file datestamp of
2019-07-19.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.26
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: glycosomal triosephosphate isomerase
Species: Trypanosoma brucei brucei [TaxId:5702]
Database cross-references and differences (RAF-indexed):
- Uniprot P04789 (225-237)
- engineered mutation (223)
- conflict (12)
- conflict (65-69)
- conflict (71-72)
- conflict (90)
Domains in SCOPe 2.08: d2vema_ - Chain 'B':
Compound: glycosomal triosephosphate isomerase
Species: Trypanosoma brucei brucei [TaxId:5702]
Database cross-references and differences (RAF-indexed):
- Uniprot P04789 (225-237)
- engineered mutation (223)
- conflict (12)
- conflict (15-16)
- conflict (65-69)
- conflict (71-72)
- conflict (90)
Domains in SCOPe 2.08: d2vemb_ - Heterogens: BBR, TBU, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2vemA (A:)
skpqpiaaanwksgspdslselidlfnstsinhdvqcvvastfvhlamtkerlshpkfvi
aaqnagnadalaslkdfgvnwivlghserrwyygetneivadkvaaavasgfmviacige
tlqeresgrtavvvltqiaaiakklkkadwakvviayepvwaigtgkvatpqqaqeahal
irswvsskigadvagelrilyggsvngknartlyqqrdvngflaglkpefvdiikatq
Sequence, based on observed residues (ATOM records): (download)
>2vemA (A:)
skpqpiaaanwksslselidlfnstsinhdvqcvvastfvhlamtkerlshpkfviaaqn
agnadalaslkdfgvnwivlghserrwyygetneivadkvaaavasgfmviacigetlqe
resgrtavvvltqiaaiakklkkadwakvviayepvwaigtgkvatpqqaqeahalirsw
vsskigadvagelrilyggsvngknartlyqqrdvngflaglkpefvdiikatq
- Chain 'B':
Sequence; same for both SEQRES and ATOM records: (download)
>2vemB (B:)
skpqpiaaanwksgspdslselidlfnstsinhdvqcvvastfvhlamtkerlshpkfvi
aaqnagnadalaslkdfgvnwivlghserrwyygetneivadkvaaavasgfmviacige
tlqeresgrtavvvltqiaaiakklkkadwakvviayepvwaigtgkvatpqqaqeahal
irswvsskigadvagelrilyggsvngknartlyqqrdvngflaglkpefvdiikatq