PDB entry 2vd6

View 2vd6 on RCSB PDB site
Description: Human adenylosuccinate lyase in complex with its substrate N6-(1,2- Dicarboxyethyl)-AMP, and its products AMP and fumarate.
Class: lyase
Keywords: purine biosynthesis, lyase, epilepsy, purine metabolism
Deposited on 2007-09-30, released 2007-10-23
The last revision prior to the SCOPe 2.08 freeze date was dated 2012-07-18, with a file datestamp of 2012-07-13.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.194
AEROSPACI score: 0.46 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: adenylosuccinate lyase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2vd6a_
  • Chain 'B':
    Compound: adenylosuccinate lyase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2vd6b_
  • Chain 'C':
    Compound: adenylosuccinate lyase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2vd6c_
  • Chain 'D':
    Compound: adenylosuccinate lyase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2vd6d_
  • Heterogens: AMP, FUM, GOL, CL, 2SA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2vd6A (A:)
mhhhhhhssgvdlgtenlyfqsmaaggdhgspdsyrsplasryaspemcfvfsdrykfrt
wrqlwlwlaeaeqtlglpitdeqiqemksnlenidfkmaaeeekrlrhdvmahvhtfghc
cpkaagiihlgatscyvgdntdliilrnaldlllpklarvisrladfakeraslptlgft
hfqpaqlttvgkrcclwiqdlcmdlqnlkrvrddlrfrgvkgttgtqasflqlfegddhk
veqldkmvtekagfkrafiitgqtytrkvdievlsvlaslgasvhkictdirllanlkem
eepfekqqigssampykrnpmrserccslarhlmtlvmdplqtasvqwfertlddsanrr
iclaeafltadtilntlqniseglvvypkvierrirqelpfmateniimamvkaggsrqd
chekirvlsqqaasvvkqeggdndlieriqvdayfspihsqldhlldpssftgrasqqvq
rfleeevypllkpyesvmkvkae

    Sequence, based on observed residues (ATOM records): (download) 
    >2vd6A (A:)
gdhgspdsyrsplasryaspemcfvfsdrykfrtwrqlwlwlaeaeqtlglpitdeqiqe
mksnlenidfkmaaeeekrlrhdvmahvhtfghccpkaagiihlgatscyvgdntdliil
rnaldlllpklarvisrladfakeraslptlgfthfqpaqlttvgkrcclwiqdlcmdlq
nlkrvrddlrfrgvkgttgtqasflqlfegddhkveqldkmvtekagfkrafiitgqtyt
rkvdievlsvlaslgasvhkictdirllanlkemeepfepykrnpmrserccslarhlmt
lvmdplqtasvqwfertlddsanrriclaeafltadtilntlqniseglvvypkvierri
rqelpfmateniimamvkaggsrqdchekirvlsqqaasvvkqeggdndlieriqvdayf
spihsqldhlldpssftgrasqqvqrfleeevypllkpyes

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2vd6B (B:)
mhhhhhhssgvdlgtenlyfqsmaaggdhgspdsyrsplasryaspemcfvfsdrykfrt
wrqlwlwlaeaeqtlglpitdeqiqemksnlenidfkmaaeeekrlrhdvmahvhtfghc
cpkaagiihlgatscyvgdntdliilrnaldlllpklarvisrladfakeraslptlgft
hfqpaqlttvgkrcclwiqdlcmdlqnlkrvrddlrfrgvkgttgtqasflqlfegddhk
veqldkmvtekagfkrafiitgqtytrkvdievlsvlaslgasvhkictdirllanlkem
eepfekqqigssampykrnpmrserccslarhlmtlvmdplqtasvqwfertlddsanrr
iclaeafltadtilntlqniseglvvypkvierrirqelpfmateniimamvkaggsrqd
chekirvlsqqaasvvkqeggdndlieriqvdayfspihsqldhlldpssftgrasqqvq
rfleeevypllkpyesvmkvkae

    Sequence, based on observed residues (ATOM records): (download) 
    >2vd6B (B:)
gdhgspdsyrsplasryaspemcfvfsdrykfrtwrqlwlwlaeaeqtlglpitdeqiqe
mksnlenidfkmaaeeekrlrhdvmahvhtfghccpkaagiihlgatscyvgdntdliil
rnaldlllpklarvisrladfakeraslptlgfthfqpaqlttvgkrcclwiqdlcmdlq
nlkrvrddlrfrgvkgttgtqasflqlfegddhkveqldkmvtekagfkrafiitgqtyt
rkvdievlsvlaslgasvhkictdirllanlkemeepfykrnpmrserccslarhlmtlv
mdplqtasvqwfertlddsanrriclaeafltadtilntlqniseglvvypkvierrirq
elpfmateniimamvkaggsrqdchekirvlsqqaasvvkqeggdndlieriqvdayfsp
ihsqldhlldpssftgrasqqvqrfleeevypllkpyesvm

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2vd6C (C:)
mhhhhhhssgvdlgtenlyfqsmaaggdhgspdsyrsplasryaspemcfvfsdrykfrt
wrqlwlwlaeaeqtlglpitdeqiqemksnlenidfkmaaeeekrlrhdvmahvhtfghc
cpkaagiihlgatscyvgdntdliilrnaldlllpklarvisrladfakeraslptlgft
hfqpaqlttvgkrcclwiqdlcmdlqnlkrvrddlrfrgvkgttgtqasflqlfegddhk
veqldkmvtekagfkrafiitgqtytrkvdievlsvlaslgasvhkictdirllanlkem
eepfekqqigssampykrnpmrserccslarhlmtlvmdplqtasvqwfertlddsanrr
iclaeafltadtilntlqniseglvvypkvierrirqelpfmateniimamvkaggsrqd
chekirvlsqqaasvvkqeggdndlieriqvdayfspihsqldhlldpssftgrasqqvq
rfleeevypllkpyesvmkvkae

    Sequence, based on observed residues (ATOM records): (download) 
    >2vd6C (C:)
gdhgspdsyrsplasryaspemcfvfsdrykfrtwrqlwlwlaeaeqtlglpitdeqiqe
mksnlenidfkmaaeeekrlrhdvmahvhtfghccpkaagiihlgatscyvgdntdliil
rnaldlllpklarvisrladfakeraslptlgfthfqpaqlttvgkrcclwiqdlcmdlq
nlkrvrddlrfrgvkgttgtqasflqlfegddhkveqldkmvtekagfkrafiitgqtyt
rkvdievlsvlaslgasvhkictdirllanlkemeepfykrnpmrserccslarhlmtlv
mdplqtasvqwfertlddsanrriclaeafltadtilntlqniseglvvypkvierrirq
elpfmateniimamvkaggsrqdchekirvlsqqaasvvkqeggdndlieriqvdayfsp
ihsqldhlldpssftgrasqqvqrfleeevypllkpy

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2vd6D (D:)
mhhhhhhssgvdlgtenlyfqsmaaggdhgspdsyrsplasryaspemcfvfsdrykfrt
wrqlwlwlaeaeqtlglpitdeqiqemksnlenidfkmaaeeekrlrhdvmahvhtfghc
cpkaagiihlgatscyvgdntdliilrnaldlllpklarvisrladfakeraslptlgft
hfqpaqlttvgkrcclwiqdlcmdlqnlkrvrddlrfrgvkgttgtqasflqlfegddhk
veqldkmvtekagfkrafiitgqtytrkvdievlsvlaslgasvhkictdirllanlkem
eepfekqqigssampykrnpmrserccslarhlmtlvmdplqtasvqwfertlddsanrr
iclaeafltadtilntlqniseglvvypkvierrirqelpfmateniimamvkaggsrqd
chekirvlsqqaasvvkqeggdndlieriqvdayfspihsqldhlldpssftgrasqqvq
rfleeevypllkpyesvmkvkae

    Sequence, based on observed residues (ATOM records): (download) 
    >2vd6D (D:)
gdhgspdsyrsplasryaspemcfvfsdrykfrtwrqlwlwlaeaeqtlglpitdeqiqe
mksnlenidfkmaaeeekrlrhdvmahvhtfghccpkaagiihlgatscyvgdntdliil
rnaldlllpklarvisrladfakeraslptlgfthfqpaqlttvgkrcclwiqdlcmdlq
nlkrvrddlrfrgvkgttgtqasflqlfegddhkveqldkmvtekagfkrafiitgqtyt
rkvdievlsvlaslgasvhkictdirllanlkemeepfpykrnpmrserccslarhlmtl
vmdplqtasvqwfertlddsanrriclaeafltadtilntlqniseglvvypkvierrir
qelpfmateniimamvkaggsrqdchekirvlsqqaasvvkqeggdndlieriqvdayfs
pihsqldhlldpssftgrasqqvqrfleeevypllkpyesvm