PDB entry 2vd6

View 2vd6 on RCSB PDB site
Description: Human adenylosuccinate lyase in complex with its substrate N6-(1,2- Dicarboxyethyl)-AMP, and its products AMP and fumarate.
Class: lyase
Keywords: purine biosynthesis, lyase, epilepsy, purine metabolism
Deposited on 2007-09-30, released 2007-10-23
The last revision prior to the SCOPe 2.08 freeze date was dated 2012-07-18, with a file datestamp of 2012-07-13.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.194
AEROSPACI score: 0.46 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: adenylosuccinate lyase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2vd6a_
  • Chain 'B':
    Compound: adenylosuccinate lyase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2vd6b_
  • Chain 'C':
    Compound: adenylosuccinate lyase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2vd6c_
  • Chain 'D':
    Compound: adenylosuccinate lyase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2vd6d_
  • Heterogens: AMP, FUM, GOL, CL, 2SA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2vd6A (A:)
    mhhhhhhssgvdlgtenlyfqsmaaggdhgspdsyrsplasryaspemcfvfsdrykfrt
    wrqlwlwlaeaeqtlglpitdeqiqemksnlenidfkmaaeeekrlrhdvmahvhtfghc
    cpkaagiihlgatscyvgdntdliilrnaldlllpklarvisrladfakeraslptlgft
    hfqpaqlttvgkrcclwiqdlcmdlqnlkrvrddlrfrgvkgttgtqasflqlfegddhk
    veqldkmvtekagfkrafiitgqtytrkvdievlsvlaslgasvhkictdirllanlkem
    eepfekqqigssampykrnpmrserccslarhlmtlvmdplqtasvqwfertlddsanrr
    iclaeafltadtilntlqniseglvvypkvierrirqelpfmateniimamvkaggsrqd
    chekirvlsqqaasvvkqeggdndlieriqvdayfspihsqldhlldpssftgrasqqvq
    rfleeevypllkpyesvmkvkae
    

    Sequence, based on observed residues (ATOM records): (download)
    >2vd6A (A:)
    gdhgspdsyrsplasryaspemcfvfsdrykfrtwrqlwlwlaeaeqtlglpitdeqiqe
    mksnlenidfkmaaeeekrlrhdvmahvhtfghccpkaagiihlgatscyvgdntdliil
    rnaldlllpklarvisrladfakeraslptlgfthfqpaqlttvgkrcclwiqdlcmdlq
    nlkrvrddlrfrgvkgttgtqasflqlfegddhkveqldkmvtekagfkrafiitgqtyt
    rkvdievlsvlaslgasvhkictdirllanlkemeepfepykrnpmrserccslarhlmt
    lvmdplqtasvqwfertlddsanrriclaeafltadtilntlqniseglvvypkvierri
    rqelpfmateniimamvkaggsrqdchekirvlsqqaasvvkqeggdndlieriqvdayf
    spihsqldhlldpssftgrasqqvqrfleeevypllkpyes
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >2vd6B (B:)
    mhhhhhhssgvdlgtenlyfqsmaaggdhgspdsyrsplasryaspemcfvfsdrykfrt
    wrqlwlwlaeaeqtlglpitdeqiqemksnlenidfkmaaeeekrlrhdvmahvhtfghc
    cpkaagiihlgatscyvgdntdliilrnaldlllpklarvisrladfakeraslptlgft
    hfqpaqlttvgkrcclwiqdlcmdlqnlkrvrddlrfrgvkgttgtqasflqlfegddhk
    veqldkmvtekagfkrafiitgqtytrkvdievlsvlaslgasvhkictdirllanlkem
    eepfekqqigssampykrnpmrserccslarhlmtlvmdplqtasvqwfertlddsanrr
    iclaeafltadtilntlqniseglvvypkvierrirqelpfmateniimamvkaggsrqd
    chekirvlsqqaasvvkqeggdndlieriqvdayfspihsqldhlldpssftgrasqqvq
    rfleeevypllkpyesvmkvkae
    

    Sequence, based on observed residues (ATOM records): (download)
    >2vd6B (B:)
    gdhgspdsyrsplasryaspemcfvfsdrykfrtwrqlwlwlaeaeqtlglpitdeqiqe
    mksnlenidfkmaaeeekrlrhdvmahvhtfghccpkaagiihlgatscyvgdntdliil
    rnaldlllpklarvisrladfakeraslptlgfthfqpaqlttvgkrcclwiqdlcmdlq
    nlkrvrddlrfrgvkgttgtqasflqlfegddhkveqldkmvtekagfkrafiitgqtyt
    rkvdievlsvlaslgasvhkictdirllanlkemeepfykrnpmrserccslarhlmtlv
    mdplqtasvqwfertlddsanrriclaeafltadtilntlqniseglvvypkvierrirq
    elpfmateniimamvkaggsrqdchekirvlsqqaasvvkqeggdndlieriqvdayfsp
    ihsqldhlldpssftgrasqqvqrfleeevypllkpyesvm
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >2vd6C (C:)
    mhhhhhhssgvdlgtenlyfqsmaaggdhgspdsyrsplasryaspemcfvfsdrykfrt
    wrqlwlwlaeaeqtlglpitdeqiqemksnlenidfkmaaeeekrlrhdvmahvhtfghc
    cpkaagiihlgatscyvgdntdliilrnaldlllpklarvisrladfakeraslptlgft
    hfqpaqlttvgkrcclwiqdlcmdlqnlkrvrddlrfrgvkgttgtqasflqlfegddhk
    veqldkmvtekagfkrafiitgqtytrkvdievlsvlaslgasvhkictdirllanlkem
    eepfekqqigssampykrnpmrserccslarhlmtlvmdplqtasvqwfertlddsanrr
    iclaeafltadtilntlqniseglvvypkvierrirqelpfmateniimamvkaggsrqd
    chekirvlsqqaasvvkqeggdndlieriqvdayfspihsqldhlldpssftgrasqqvq
    rfleeevypllkpyesvmkvkae
    

    Sequence, based on observed residues (ATOM records): (download)
    >2vd6C (C:)
    gdhgspdsyrsplasryaspemcfvfsdrykfrtwrqlwlwlaeaeqtlglpitdeqiqe
    mksnlenidfkmaaeeekrlrhdvmahvhtfghccpkaagiihlgatscyvgdntdliil
    rnaldlllpklarvisrladfakeraslptlgfthfqpaqlttvgkrcclwiqdlcmdlq
    nlkrvrddlrfrgvkgttgtqasflqlfegddhkveqldkmvtekagfkrafiitgqtyt
    rkvdievlsvlaslgasvhkictdirllanlkemeepfykrnpmrserccslarhlmtlv
    mdplqtasvqwfertlddsanrriclaeafltadtilntlqniseglvvypkvierrirq
    elpfmateniimamvkaggsrqdchekirvlsqqaasvvkqeggdndlieriqvdayfsp
    ihsqldhlldpssftgrasqqvqrfleeevypllkpy
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >2vd6D (D:)
    mhhhhhhssgvdlgtenlyfqsmaaggdhgspdsyrsplasryaspemcfvfsdrykfrt
    wrqlwlwlaeaeqtlglpitdeqiqemksnlenidfkmaaeeekrlrhdvmahvhtfghc
    cpkaagiihlgatscyvgdntdliilrnaldlllpklarvisrladfakeraslptlgft
    hfqpaqlttvgkrcclwiqdlcmdlqnlkrvrddlrfrgvkgttgtqasflqlfegddhk
    veqldkmvtekagfkrafiitgqtytrkvdievlsvlaslgasvhkictdirllanlkem
    eepfekqqigssampykrnpmrserccslarhlmtlvmdplqtasvqwfertlddsanrr
    iclaeafltadtilntlqniseglvvypkvierrirqelpfmateniimamvkaggsrqd
    chekirvlsqqaasvvkqeggdndlieriqvdayfspihsqldhlldpssftgrasqqvq
    rfleeevypllkpyesvmkvkae
    

    Sequence, based on observed residues (ATOM records): (download)
    >2vd6D (D:)
    gdhgspdsyrsplasryaspemcfvfsdrykfrtwrqlwlwlaeaeqtlglpitdeqiqe
    mksnlenidfkmaaeeekrlrhdvmahvhtfghccpkaagiihlgatscyvgdntdliil
    rnaldlllpklarvisrladfakeraslptlgfthfqpaqlttvgkrcclwiqdlcmdlq
    nlkrvrddlrfrgvkgttgtqasflqlfegddhkveqldkmvtekagfkrafiitgqtyt
    rkvdievlsvlaslgasvhkictdirllanlkemeepfpykrnpmrserccslarhlmtl
    vmdplqtasvqwfertlddsanrriclaeafltadtilntlqniseglvvypkvierrir
    qelpfmateniimamvkaggsrqdchekirvlsqqaasvvkqeggdndlieriqvdayfs
    pihsqldhlldpssftgrasqqvqrfleeevypllkpyesvm