PDB entry 2vbo

View 2vbo on RCSB PDB site
Description: Molecular basis of human XPC gene recognition and cleavage by engineered homing endonuclease heterodimers
Class: hydrolase
Keywords: uv-induced DNA damage, cutting DNA endonucleases, nuclease, hydrolase, chloroplast, endonuclease, intron homing, ini3-4-calcium, double strand break (dsb), homing endonucleases (hes)
Deposited on 2007-09-14, released 2008-10-28
The last revision prior to the SCOPe 2.08 freeze date was dated 2012-06-20, with a file datestamp of 2012-06-15.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.153
AEROSPACI score: 0.54 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: DNA endonuclease I-crei
  Species: Chlamydomonas reinhardtii [TaxId:3055]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P05725 (0-152)
    • conflict (32)
    • conflict (37)
    • conflict (41)
    • conflict (69)
    • conflict (74)
    • conflict (109-110)
  Domains in SCOPe 2.08: d2vboa_
• Chain 'B':
  Compound: DNA endonuclease I-crei
  Species: Chlamydomonas reinhardtii [TaxId:3055]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P05725 (Start-152)
    • conflict (27)
    • conflict (37)
    • conflict (39)
    • conflict (41)
    • conflict (43)
    • conflict (67)
    • conflict (69)
    • conflict (74)
    • conflict (109-110)
  Domains in SCOPe 2.08: d2vbob_
• Chain 'C':
  Compound: 5'-d(*tp*cp*tp*gp*cp*cp*tp*tp*tp*tp *tp*tp*gp*ap*ap*gp*gp*ap*tp*cp*cp*tp*ap*a)-3'
  
• Chain 'E':
  Compound: 5'-d(*tp*tp*ap*gp*gp*ap*tp*cp*cp*tp *tp*cp*ap*ap*ap*ap*ap*ap*gp*gp*cp*ap*gp*a)-3'
  
• Heterogens: CA, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >2vboA (A:)
  mntkynkefllylagfvdgdgsiiaqikpnqsskfkhrlsltfqvtqktqrrwfldklvd
  eigvgyvrdsgsvsnyilseikplhnfltqlqpflklkqkqanlvlkiieqlpsakespd
  kflevctwvdqiaalndsktrkttsetvravld
  

  
  
• Chain 'B':
  Sequence, based on SEQRES records: (download)
  

  >2vboB (B:)
  mntkynkefllylagfvdgdgsiiaqiepnqsykfkhrlkltfkvtqktqrrwfldklvd
  eigvgyvsdsgsvsnyilseikplhnfltqlqpflklkqkqanlvlkiieqlpsakespd
  kflevctwvdqiaalndsktrkttsetvravld
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >2vboB (B:)
  ntkynkefllylagfvdgdgsiiaqiepnqsykfkhrlkltfkvtqktqrrwfldklvde
  igvgyvsdsgsvsnyilseikplhnfltqlqpflklkqkqanlvlkiieqlpsakespdk
  flevctwvdqiaalndsktrkttsetvravld
  

  
  
• Chain 'C':
  No sequence available.
  
  
• Chain 'E':
  No sequence available.