PDB entry 2vag

View 2vag on RCSB PDB site
Description: crystal structure of di-phosphorylated human clk1 in complex with a novel substituted indole inhibitor
Class: transferase
Keywords: serine/threonine-protein kinase, tyrosine-protein kinase, nucleus, transferase
Deposited on 2007-08-31, released 2007-10-09
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-12-07, with a file datestamp of 2011-12-02.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.182
AEROSPACI score: 0.52 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dual specificity protein kinase CLK1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P49759 (2-End)
      • expression tag (1)
      • conflict (286)
    Domains in SCOPe 2.08: d2vaga1, d2vaga2
  • Heterogens: V25, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2vagA (A:)
    smhlicqsgdvlsaryeivdtlgegafgkvvecidhkaggrhvavkivknvdryceaars
    eiqvlehlnttdpnstfrcvqmlewfehhghicivfellglstydfikengflpfrldhi
    rkmayqicksvnflhsnklthtdlkpenilfvqsdyteaynpkikrdertlinpdikvvd
    fgsatyddehhstlvstrhyrapevilalgwsqpcdvwsigcilieyylgftvfpthdsk
    ehlammerilgplpkhmiqktrkrkyfhhdrldwdehssagryvsrackplkefmlsqdv
    eherlfdliqkmleydpakritlrealkhpffdllkksi
    

    Sequence, based on observed residues (ATOM records): (download)
    >2vagA (A:)
    mhlicqsgdvlsaryeivdtlgegafgkvvecidhkaggrhvavkivknvdryceaarse
    iqvlehlnttdpnstfrcvqmlewfehhghicivfellglstydfikengflpfrldhir
    kmayqicksvnflhsnklthtdlkpenilfvqsdyteaynkrdertlinpdikvvdfgsa
    tyddehhstlvstrhyrapevilalgwsqpcdvwsigcilieyylgftvfpthdskehla
    mmerilgplpkhmiqktrkrkyfhhdrldwdehssagryvsrackplkefmlsqdveher
    lfdliqkmleydpakritlrealkhpffdllk