PDB entry 2vag
View 2vag on RCSB PDB site
Description: crystal structure of di-phosphorylated human clk1 in complex with a novel substituted indole inhibitor
Class: transferase
Keywords: serine/threonine-protein kinase, tyrosine-protein kinase, nucleus, transferase
Deposited on
2007-08-31, released
2007-10-09
The last revision prior to the SCOPe 2.08 freeze date was dated
2011-12-07, with a file datestamp of
2011-12-02.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.182
AEROSPACI score: 0.52
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Dual specificity protein kinase CLK1
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot P49759 (2-End)
- expression tag (1)
- conflict (286)
Domains in SCOPe 2.08: d2vaga1, d2vaga2 - Heterogens: V25, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2vagA (A:)
smhlicqsgdvlsaryeivdtlgegafgkvvecidhkaggrhvavkivknvdryceaars
eiqvlehlnttdpnstfrcvqmlewfehhghicivfellglstydfikengflpfrldhi
rkmayqicksvnflhsnklthtdlkpenilfvqsdyteaynpkikrdertlinpdikvvd
fgsatyddehhstlvstrhyrapevilalgwsqpcdvwsigcilieyylgftvfpthdsk
ehlammerilgplpkhmiqktrkrkyfhhdrldwdehssagryvsrackplkefmlsqdv
eherlfdliqkmleydpakritlrealkhpffdllkksi
Sequence, based on observed residues (ATOM records): (download)
>2vagA (A:)
mhlicqsgdvlsaryeivdtlgegafgkvvecidhkaggrhvavkivknvdryceaarse
iqvlehlnttdpnstfrcvqmlewfehhghicivfellglstydfikengflpfrldhir
kmayqicksvnflhsnklthtdlkpenilfvqsdyteaynkrdertlinpdikvvdfgsa
tyddehhstlvstrhyrapevilalgwsqpcdvwsigcilieyylgftvfpthdskehla
mmerilgplpkhmiqktrkrkyfhhdrldwdehssagryvsrackplkefmlsqdveher
lfdliqkmleydpakritlrealkhpffdllk