PDB entry 2v7a
View 2v7a on RCSB PDB site
Description: crystal structure of the t315i abl mutant in complex with the inhibitor pha-739358
Class: transferase
Keywords: kinase, nucleus, myristate, cytoplasm, manganese, cell adhesion, metal-binding, proto-oncogene, tyrosine-protein kinase, chromosomal rearrangement, transferase, lipoprotein, polymorphism, cytoskeleton, magnesium, sh2 domain, sh3 domain, ATP-binding, nucleotide-binding, alternative splicing, phosphorylation, kinase inhibitor, t315i abl mutant
Deposited on
2007-07-27, released
2007-09-18
The last revision prior to the SCOPe 2.03 freeze date was dated
2009-02-24, with a file datestamp of
2009-03-01.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.209
AEROSPACI score: 0.31
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Proto-oncogene tyrosine-protein kinase ABL1
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.03: d2v7aa_ - Chain 'B':
Compound: Proto-oncogene tyrosine-protein kinase ABL1
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.03: d2v7ab_ - Heterogens: 627, MG, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2v7aA (A:)
gpspnydkwemertditmkhklgggqygevyegvwkkysltvavktlkedtmeveeflke
aavmkeikhpnlvqllgvctreppfyiiiefmtygnlldylrecnrqevnavvllymatq
issameylekknfihrdlaarnclvgenhlvkvadfglsrlmtgdtytahagakfpikwt
apeslaynkfsiksdvwafgvllweiatygmspypgidlsqvyellekdyrmerpegcpe
kvyelmracwqwnpsdrpsfaeihqafetmfqessisdevekelgk
Sequence, based on observed residues (ATOM records): (download)
>2v7aA (A:)
dkwemertditmkhklgggqygevyegvwkkysltvavktlkedtmeveeflkeaavmke
ikhpnlvqllgvctreppfyiiiefmtygnlldylrecnrqevnavvllymatqissame
ylekknfihrdlaarnclvgenhlvkvadfglsrlmtgdtytahagakfpikwtapesla
ynkfsiksdvwafgvllweiatygmspypgidlsqvyellekdyrmerpegcpekvyelm
racwqwnpsdrpsfaeihqafetmfqessis
- Chain 'B':
Sequence, based on SEQRES records: (download)
>2v7aB (B:)
gpspnydkwemertditmkhklgggqygevyegvwkkysltvavktlkedtmeveeflke
aavmkeikhpnlvqllgvctreppfyiiiefmtygnlldylrecnrqevnavvllymatq
issameylekknfihrdlaarnclvgenhlvkvadfglsrlmtgdtytahagakfpikwt
apeslaynkfsiksdvwafgvllweiatygmspypgidlsqvyellekdyrmerpegcpe
kvyelmracwqwnpsdrpsfaeihqafetmfqessisdevekelgk
Sequence, based on observed residues (ATOM records): (download)
>2v7aB (B:)
kwemertditmkhklgggqygevyegvwkkysltvavktlkedtmeveeflkeaavmkei
khpnlvqllgvctreppfyiiiefmtygnlldylrecnrqevnavvllymatqissamey
lekknfihrdlaarnclvgenhlvkvadfglsrlmtgdtytahagakfpikwtapeslay
nkfsiksdvwafgvllweiatygmspypgidlsqvyellekdyrmerpegcpekvyelmr
acwqwnpsdrpsfaeihqafetmfqessis