PDB entry 2v74

View 2v74 on RCSB PDB site
Description: Crystal structure of coactivator-associated arginine methyltransferase 1 (CARM1), in complex with S-adenosyl-homocysteine
Class: transferase
Keywords: arginine methyltransferase, s-adenosyl-l-methionine, transcription regulation, alternative splicing, histone modification, co- activator, methyltransferase, chromatin regulator, nucleus, cytoplasm, transferase, transcription
Deposited on 2007-07-26, released 2007-10-02
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-01-24, with a file datestamp of 2018-01-19.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'B':
    Compound: histone-arginine methyltransferase carm1
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 2V74
    • Uniprot Q9WVG6 (2-End)
    Domains in SCOPe 2.08: d2v74b_
  • Chain 'D':
    Compound: histone-arginine methyltransferase carm1
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2v74d_
  • Chain 'F':
    Compound: histone-arginine methyltransferase carm1
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 2V74
    • Uniprot Q9WVG6 (2-End)
    Domains in SCOPe 2.08: d2v74f_
  • Chain 'H':
    Compound: histone-arginine methyltransferase carm1
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2v74h_
  • Heterogens: SAH, HOH

PDB Chain Sequences:

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2v74B (B:)
gaavqyfqfygylsqqqnmmqdyvrtgtyqrailqnhtdfkdkivldvgcgsgilsffaa
qagarkiyaveastmaqhaevlvksnnltdrivvipgkveevslpeqvdiiisepmgyml
fnermlesylhakkylkpsgnmfptigdvhlapftdeqlymeqftkanfwyqpsfhgvdl
salrgaavdeyfrqpvvdtfdirilmaksvkytvnfleakegdlhrieipfkfhmlhsgl
vhglafwfdvafigsimtvwlstapteplthwyqvrclfqsplfakagdtlsgtcllian
krqsydisivaqvdqtgskssnlldlknpffrytgttpspppgshy

    Sequence, based on observed residues (ATOM records): (download) 
    >2v74B (B:)
avqyfqfygylsqqqnmmqdyvrtgtyqrailqnhtdfkdkivldvgcgsgilsffaaqa
garkiyaveastmaqhaevlvksnnltdrivvipgkveevslpeqvdiiisepmgymlfn
ermlesylhakkylkpsgnmfptigdvhlapftdeqlymeqftkanfwyqpsfhgvdlsa
lrgaavdeyfrqpvvdtfdirilmaksvkytvnfleakegdlhrieipfkfhmlhsglvh
glafwfdvafigsimtvwlstapteplthwyqvrclfqsplfakagdtlsgtclliankr
qsydisivaqvdqtgskssnlldlknpffry

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2v74D (D:)
gaavqyfqfygylsqqqnmmqdyvrtgtyqrailqnhtdfkdkivldvgcgsgilsffaa
qagarkiyaveastmaqhaevlvksnnltdrivvipgkveevslpeqvdiiisepmgyml
fnermlesylhakkylkpsgnmfptigdvhlapftdeqlymeqftkanfwyqpsfhgvdl
salrgaavdeyfrqpvvdtfdirilmaksvkytvnfleakegdlhrieipfkfhmlhsgl
vhglafwfdvafigsimtvwlstapteplthwyqvrclfqsplfakagdtlsgtcllian
krqsydisivaqvdqtgskssnlldlknpffrytgttpspppgshy

    Sequence, based on observed residues (ATOM records): (download) 
    >2v74D (D:)
vqyfqfygylsqqqnmmqdyvrtgtyqrailqnhtdfkdkivldvgcgsgilsffaaqag
arkiyaveastmaqhaevlvksnnltdrivvipgkveevslpeqvdiiisepmgymlfne
rmlesylhakkylkpsgnmfptigdvhlapftdeqlymeqftkanfwyqpsfhgvdlsal
rgaavdeyfrqpvvdtfdirilmaksvkytvnfleakegdlhrieipfkfhmlhsglvhg
lafwfdvafigsimtvwlstapteplthwyqvrclfqsplfakagdtlsgtclliankrq
sydisivaqvdqtgskssnlldlknpffrytgt

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >2v74F (F:)
gaavqyfqfygylsqqqnmmqdyvrtgtyqrailqnhtdfkdkivldvgcgsgilsffaa
qagarkiyaveastmaqhaevlvksnnltdrivvipgkveevslpeqvdiiisepmgyml
fnermlesylhakkylkpsgnmfptigdvhlapftdeqlymeqftkanfwyqpsfhgvdl
salrgaavdeyfrqpvvdtfdirilmaksvkytvnfleakegdlhrieipfkfhmlhsgl
vhglafwfdvafigsimtvwlstapteplthwyqvrclfqsplfakagdtlsgtcllian
krqsydisivaqvdqtgskssnlldlknpffrytgttpspppgshy

    Sequence, based on observed residues (ATOM records): (download) 
    >2v74F (F:)
avqyfqfygylsqqqnmmqdyvrtgtyqrailqnhtdfkdkivldvgcgsgilsffaaqa
garkiyaveastmaqhaevlvksnnltdrivvipgkveevslpeqvdiiisepmgymlfn
ermlesylhakkylkpsgnmfptigdvhlapftdeqlymeqftkanfwyqpsfhgvdlsa
lrgaavdeyfrqpvvdtfdirilmaksvkytvnfleakegdlhrieipfkfhmlhsglvh
glafwfdvafigsimtvwlstapteplthwyqvrclfqsplfakagdtlsgtclliankr
qsydisivaqvdqtgskssnlldlknpffryt

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >2v74H (H:)
gaavqyfqfygylsqqqnmmqdyvrtgtyqrailqnhtdfkdkivldvgcgsgilsffaa
qagarkiyaveastmaqhaevlvksnnltdrivvipgkveevslpeqvdiiisepmgyml
fnermlesylhakkylkpsgnmfptigdvhlapftdeqlymeqftkanfwyqpsfhgvdl
salrgaavdeyfrqpvvdtfdirilmaksvkytvnfleakegdlhrieipfkfhmlhsgl
vhglafwfdvafigsimtvwlstapteplthwyqvrclfqsplfakagdtlsgtcllian
krqsydisivaqvdqtgskssnlldlknpffrytgttpspppgshy

    Sequence, based on observed residues (ATOM records): (download) 
    >2v74H (H:)
vqyfqfygylsqqqnmmqdyvrtgtyqrailqnhtdfkdkivldvgcgsgilsffaaqag
arkiyaveastmaqhaevlvksnnltdrivvipgkveevslpeqvdiiisepmgymlfne
rmlesylhakkylkpsgnmfptigdvhlapftdeqlymeqftkanfwyqpsfhgvdlsal
rgaavdeyfrqpvvdtfdirilmaksvkytvnfleakegdlhrieipfkfhmlhsglvhg
lafwfdvafigsimtvwlstapteplthwyqvrclfqsplfakagdtlsgtclliankrq
sydisivaqvdqtgskssnlldlknpffry