PDB entry 2v5w
View 2v5w on RCSB PDB site
Description: Crystal structure of HDAC8-substrate complex
Class: hydrolase/hydrolase substrate
Keywords: histone deacetylase, chromatin regulator, p53, hdac, hdac8, nucleus, repressor, hydrolase, nuclear protein, peptidic substrate, transcription regulation, chromatin, transcription, deacetylation, hydrolase-hydrolase substrate complex
Deposited on
2007-07-10, released
2007-09-04
The last revision prior to the SCOPe 2.08 freeze date was dated
2019-05-29, with a file datestamp of
2019-05-24.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.31
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Histone deacetylase 8
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot Q9BY41 (Start-376)
- engineered mutation (305)
- PDB 2V5W
Domains in SCOPe 2.08: d2v5wa_ - Chain 'B':
Compound: Histone deacetylase 8
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot Q9BY41
- engineered mutation (305)
- PDB 2V5W
Domains in SCOPe 2.08: d2v5wb_ - Chain 'G':
Compound: glycyl-glycyl-glycine
Species: synthetic construct, synthetic [TaxId:32630]
Database cross-references and differences (RAF-indexed):
- Chain 'I':
Compound: peptidic substrate
Species: synthetic construct, synthetic [TaxId:32630]
Database cross-references and differences (RAF-indexed):
- Chain 'L':
Compound: peptidic substrate
Species: synthetic construct, synthetic [TaxId:32630]
Database cross-references and differences (RAF-indexed):
- Heterogens: K, ZN, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2v5wA (A:)
meepeepadsgqslvpvyiyspeyvsmcdslakipkrasmvhslieayalhkqmrivkpk
vasmeematfhtdaylqhlqkvsqegdddhpdsieyglgydcpategifdyaaaiggati
taaqclidgmckvainwsggwhhakkdeasgfcylndavlgilrlrrkferilyvdldlh
hgdgvedafsftskvmtvslhkfspgffpgtgdvsdvglgkgryysvnvpiqdgiqdeky
yqicesvlkevyqafnpkavvlqlgadtiagdpmcsfnmtpvgigkclkyilqwqlatli
lggggfnlantarcwtyltgvilgktlsseipdhefftaygpdyvleitpscrpdrneph
riqqilnyikgnlkhvviegrshhhhhh
Sequence, based on observed residues (ATOM records): (download)
>2v5wA (A:)
vpvyiyspeyvsmcdslakipkrasmvhslieayalhkqmrivkpkvasmeematfhtda
ylqhlqkvsqegdddhpdsieyglgydcpategifdyaaaiggatitaaqclidgmckva
inwsggwhhakkdeasgfcylndavlgilrlrrkferilyvdldlhhgdgvedafsftsk
vmtvslhkfspgffpgtgdvsdvglgkgryysvnvpiqdgiqdekyyqicesvlkevyqa
fnpkavvlqlgadtiagdpmcsfnmtpvgigkclkyilqwqlatlilggggfnlantarc
wtyltgvilgktlsseipdhefftaygpdyvleitpscrpdrnephriqqilnyikgnlk
hvv
- Chain 'B':
Sequence, based on SEQRES records: (download)
>2v5wB (B:)
meepeepadsgqslvpvyiyspeyvsmcdslakipkrasmvhslieayalhkqmrivkpk
vasmeematfhtdaylqhlqkvsqegdddhpdsieyglgydcpategifdyaaaiggati
taaqclidgmckvainwsggwhhakkdeasgfcylndavlgilrlrrkferilyvdldlh
hgdgvedafsftskvmtvslhkfspgffpgtgdvsdvglgkgryysvnvpiqdgiqdeky
yqicesvlkevyqafnpkavvlqlgadtiagdpmcsfnmtpvgigkclkyilqwqlatli
lggggfnlantarcwtyltgvilgktlsseipdhefftaygpdyvleitpscrpdrneph
riqqilnyikgnlkhvviegrshhhhhh
Sequence, based on observed residues (ATOM records): (download)
>2v5wB (B:)
sgqslvpvyiyspeyvsmcdslakipkrasmvhslieayalhkqmrivkpkvasmeemat
fhtdaylqhlqkvsqegdddhpdsieyglgydcpategifdyaaaiggatitaaqclidg
mckvainwsggwhhakkdeasgfcylndavlgilrlrrkferilyvdldlhhgdgvedaf
sftskvmtvslhkfspgffpgtgdvsdvglgkgryysvnvpiqdgiqdekyyqicesvlk
evyqafnpkavvlqlgadtiagdpmcsfnmtpvgigkclkyilqwqlatlilggggfnla
ntarcwtyltgvilgktlsseipdhefftaygpdyvleitpscrpdrnephriqqilnyi
kgnlkhv
- Chain 'G':
No sequence available.
- Chain 'I':
No sequence available.
- Chain 'L':
No sequence available.