PDB entry 2v3f

View 2v3f on RCSB PDB site
Description: acid-beta-glucosidase produced in carrot
Class: hydrolase
Keywords: alternative initiation, sphingolipid metabolism, gaucher disease, disease mutation, lipid metabolism, polymorphism, glycoprotein, pharmaceutical, n-butyl-deoxynojirimycin, alternative splicing, acid-beta-glucosidase, membrane, lysosome, hydrolase, glycosidase
Deposited on 2007-06-17, released 2008-04-08
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-06-29.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: N/A
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: glucosylceramidase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2V3F (499-End)
      • conflict (496)
    • Uniprot P04062 (2-498)
    Domains in SCOPe 2.08: d2v3fa1, d2v3fa2
  • Chain 'B':
    Compound: glucosylceramidase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2V3F
      • conflict (496)
    • Uniprot P04062 (2-498)
    Domains in SCOPe 2.08: d2v3fb1, d2v3fb2
  • Heterogens: BTB, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2v3fA (A:)
efarpcipksfgyssvvcvcnatycdsfdpptfpalgtfsryestrsgrrmelsmgpiqa
nhtgtgllltlqpeqkfqkvkgfggamtdaaalnilalsppaqnlllksyfseegigyni
irvpmascdfsirtytyadtpddfqlhnfslpeedtklkiplihralqlaqrpvsllasp
wtsptwlktngavngkgslkgqpgdiyhqtwaryfvkfldayaehklqfwavtaenepsa
gllsgypfqclgftpehqrdfiardlgptlansthhnvrllmlddqrlllphwakvvltd
peaakyvhgiavhwyldflapakatlgethrlfpntmlfaseacvgskfweqsvrlgswd
rgmqyshsiitnllyhvvgwtdwnlalnpeggpnwvrnfvdspiivditkdtfykqpmfy
hlghfskfipegsqrvglvasqkndldavalmhpdgsavvvvlnrsskdvpltikdpavg
fletispgysihtylwhrqllvdtm

    Sequence, based on observed residues (ATOM records): (download) 
    >2v3fA (A:)
efarpcipksfgyssvvcvcnatycdsfdppalgtfsryestrsgrrmelsmgpiqanht
gtgllltlqpeqkfqkvkgfggamtdaaalnilalsppaqnlllksyfseegigyniirv
pmascdfsirtytyadtpddfqlhnfslpeedtklkiplihralqlaqrpvsllaspwts
ptwlktngavngkgslkgqpgdiyhqtwaryfvkfldayaehklqfwavtaenepsagll
sgypfqclgftpehqrdfiardlgptlansthhnvrllmlddqrlllphwakvvltdpea
akyvhgiavhwyldflapakatlgethrlfpntmlfaseacvgskfweqsvrlgswdrgm
qyshsiitnllyhvvgwtdwnlalnpeggpnwvrnfvdspiivditkdtfykqpmfyhlg
hfskfipegsqrvglvasqkndldavalmhpdgsavvvvlnrsskdvpltikdpavgfle
tispgysihtylwhrql

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2v3fB (B:)
efarpcipksfgyssvvcvcnatycdsfdpptfpalgtfsryestrsgrrmelsmgpiqa
nhtgtgllltlqpeqkfqkvkgfggamtdaaalnilalsppaqnlllksyfseegigyni
irvpmascdfsirtytyadtpddfqlhnfslpeedtklkiplihralqlaqrpvsllasp
wtsptwlktngavngkgslkgqpgdiyhqtwaryfvkfldayaehklqfwavtaenepsa
gllsgypfqclgftpehqrdfiardlgptlansthhnvrllmlddqrlllphwakvvltd
peaakyvhgiavhwyldflapakatlgethrlfpntmlfaseacvgskfweqsvrlgswd
rgmqyshsiitnllyhvvgwtdwnlalnpeggpnwvrnfvdspiivditkdtfykqpmfy
hlghfskfipegsqrvglvasqkndldavalmhpdgsavvvvlnrsskdvpltikdpavg
fletispgysihtylwhrqllvdtm

    Sequence, based on observed residues (ATOM records): (download) 
    >2v3fB (B:)
arpcipksfgyssvvcvcnatycdsfalgtfsryestrsgrrmelsmgpiqanhtgtgll
ltlqpeqkfqkvkgfggamtdaaalnilalsppaqnlllksyfseegigyniirvpmasc
dfsirtytyadtpddfqlhnfslpeedtklkiplihralqlaqrpvsllaspwtsptwlk
tngavngkgslkgqpgdiyhqtwaryfvkfldayaehklqfwavtaenepsagllsgypf
qclgftpehqrdfiardlgptlansthhnvrllmlddqrlllphwakvvltdpeaakyvh
giavhwyldflapakatlgethrlfpntmlfaseacvgskfweqsvrlgswdrgmqyshs
iitnllyhvvgwtdwnlalnpeggpnwvrnfvdspiivditkdtfykqpmfyhlghfskf
ipegsqrvglvasqkndldavalmhpdgsavvvvlnrsskdvpltikdpavgfletispg
ysihtylwhrq