PDB entry 2v3e

View 2v3e on RCSB PDB site
Description: acid-beta-glucosidase with N-nonyl-deoxynojirimycin
Class: hydrolase
Keywords: acid-beta-glucosidase, n-nonyl-deoxynojirimycinalternative initiation, sphingolipid metabolism, n-nonyl-deoxynojirimycin, gaucher disease, disease mutation, lipid metabolism, polymorphism, glycoprotein, pharmaceutical, alternative splicing, membrane, lysosome, hydrolase, glycosidase
Deposited on 2007-06-17, released 2007-08-21
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-06-29.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: glucosylceramidase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2V3E
      • conflict (496)
    • Uniprot P04062 (2-498)
    Domains in SCOPe 2.08: d2v3ea1, d2v3ea2
  • Chain 'B':
    Compound: glucosylceramidase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2V3E
      • conflict (496)
    • Uniprot P04062 (2-498)
    Domains in SCOPe 2.08: d2v3eb1, d2v3eb2
  • Heterogens: NND, PO4, NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2v3eA (A:)
efarpcipksfgyssvvcvcnatycdsfdpptfpalgtfsryestrsgrrmelsmgpiqa
nhtgtgllltlqpeqkfqkvkgfggamtdaaalnilalsppaqnlllksyfseegigyni
irvpmascdfsirtytyadtpddfqlhnfslpeedtklkiplihralqlaqrpvsllasp
wtsptwlktngavngkgslkgqpgdiyhqtwaryfvkfldayaehklqfwavtaenepsa
gllsgypfqclgftpehqrdfiardlgptlansthhnvrllmlddqrlllphwakvvltd
peaakyvhgiavhwyldflapakatlgethrlfpntmlfaseacvgskfweqsvrlgswd
rgmqyshsiitnllyhvvgwtdwnlalnpeggpnwvrnfvdspiivditkdtfykqpmfy
hlghfskfipegsqrvglvasqkndldavalmhpdgsavvvvlnrsskdvpltikdpavg
fletispgysihtylwhrqllvdtm

    Sequence, based on observed residues (ATOM records): (download) 
    >2v3eA (A:)
efarpcipksfgyssvvcvcnatycdsfdpptpalgtfsryestrsgrrmelsmgpiqan
htgtgllltlqpeqkfqkvkgfggamtdaaalnilalsppaqnlllksyfseegigynii
rvpmascdfsirtytyadtpddfqlhnfslpeedtklkiplihralqlaqrpvsllaspw
tsptwlktngavngkgslkgqpgdiyhqtwaryfvkfldayaehklqfwavtaenepsag
llsgypfqclgftpehqrdfiardlgptlansthhnvrllmlddqrlllphwakvvltdp
eaakyvhgiavhwyldflapakatlgethrlfpntmlfaseacvgskfweqsvrlgswdr
gmqyshsiitnllyhvvgwtdwnlalnpeggpnwvrnfvdspiivditkdtfykqpmfyh
lghfskfipegsqrvglvasqkndldavalmhpdgsavvvvlnrsskdvpltikdpavgf
letispgysihtylwhrq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2v3eB (B:)
efarpcipksfgyssvvcvcnatycdsfdpptfpalgtfsryestrsgrrmelsmgpiqa
nhtgtgllltlqpeqkfqkvkgfggamtdaaalnilalsppaqnlllksyfseegigyni
irvpmascdfsirtytyadtpddfqlhnfslpeedtklkiplihralqlaqrpvsllasp
wtsptwlktngavngkgslkgqpgdiyhqtwaryfvkfldayaehklqfwavtaenepsa
gllsgypfqclgftpehqrdfiardlgptlansthhnvrllmlddqrlllphwakvvltd
peaakyvhgiavhwyldflapakatlgethrlfpntmlfaseacvgskfweqsvrlgswd
rgmqyshsiitnllyhvvgwtdwnlalnpeggpnwvrnfvdspiivditkdtfykqpmfy
hlghfskfipegsqrvglvasqkndldavalmhpdgsavvvvlnrsskdvpltikdpavg
fletispgysihtylwhrqllvdtm

    Sequence, based on observed residues (ATOM records): (download) 
    >2v3eB (B:)
farpcipksfgyssvvcvcnatycdsfdpptfpalgtfsryestrsgrrmelsmgpiqan
htgtgllltlqpeqkfqkvkgfggamtdaaalnilalsppaqnlllksyfseegigynii
rvpmascdfsirtytyadtpddfqlhnfslpeedtklkiplihralqlaqrpvsllaspw
tsptwlktngavngkgslkgqpgdiyhqtwaryfvkfldayaehklqfwavtaenepsag
llsgypfqclgftpehqrdfiardlgptlansthhnvrllmlddqrlllphwakvvltdp
eaakyvhgiavhwyldflapakatlgethrlfpntmlfaseacvgskfweqsvrlgswdr
gmqyshsiitnllyhvvgwtdwnlalnpeggpnwvrnfvdspiivditkdtfykqpmfyh
lghfskfipegsqrvglvasqkndldavalmhpdgsavvvvlnrsskdvpltikdpavgf
letispgysihtylwhrq