PDB entry 2v2w

View 2v2w on RCSB PDB site
Description: t cell cross-reactivity and conformational changes during tcr engagement
Class: immune system
Keywords: immunoglobulin domain, complex (antigen-peptide), tcr, hiv, MHC, aids, MHC I, hla-a2, membrane, immunoglobulin domain, host-virus interaction, pyrrolidone carboxylic acid, immune system, complex (antigen/peptide), ubl conjugation, immune response, disease mutation, polymorphism, glycoprotein, transmembrane
Deposited on 2007-06-07, released 2007-11-06
The last revision prior to the SCOP 1.75 freeze date was dated 2007-11-06, with a file datestamp of 2007-11-02.
Experiment type: XRAY
Resolution: 1.6 Å
R-factor: 0.20048
AEROSPACI score: 0.68 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: HLA class I histocompatibility antigen, A-2 alpha chain
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d2v2wa1, d2v2wa2
  • Chain 'B':
    Compound: beta-2 microglobulin
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed):
    • PDB 2V2W (1-9)
    • Uniprot P61769 (1-99)
    Domains in SCOP 1.75: d2v2wb1
  • Chain 'C':
    Compound: hiv p17
  • Chain 'D':
    Compound: HLA class I histocompatibility antigen, A-2 alpha chain
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d2v2wd1, d2v2wd2
  • Chain 'E':
    Compound: beta-2 microglobulin
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed):
    • PDB 2V2W (1-9)
    • Uniprot P61769 (1-99)
    Domains in SCOP 1.75: d2v2we1
  • Chain 'F':
    Compound: hiv p17
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2v2wA (A:)
    gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
    dgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
    kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketlq
    rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
    fqkwaavvvpsgqeqrytchvqheglpkpltlrwep
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2v2wB (B:)
    miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
    wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2v2wD (D:)
    gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
    dgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
    kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketlq
    rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
    fqkwaavvvpsgqeqrytchvqheglpkpltlrwep
    

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2v2wE (E:)
    miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
    wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'F':
    No sequence available.