PDB entry 2v2w

View 2v2w on RCSB PDB site
Description: t cell cross-reactivity and conformational changes during tcr engagement
Class: immune system
Keywords: immunoglobulin domain, complex (antigen-peptide), tcr, hiv, MHC, aids, MHC I, hla-a2, membrane, host-virus interaction, pyrrolidone carboxylic acid, immune system, complex (antigen/peptide), ubl conjugation, immune response, disease mutation, polymorphism, glycoprotein, transmembrane
Deposited on 2007-06-07, released 2007-11-06
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 1.6 Å
R-factor: 0.2
AEROSPACI score: 0.57 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: HLA class I histocompatibility antigen, A-2 alpha chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2v2wa1, d2v2wa2
  • Chain 'B':
    Compound: beta-2 microglobulin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2V2W (1-9)
    • Uniprot P61769 (1-99)
    Domains in SCOPe 2.08: d2v2wb2, d2v2wb3
  • Chain 'C':
    Compound: hiv p17
    Species: HUMAN IMMUNODEFICIENCY VIRUS, synthetic [TaxId:12721]
  • Chain 'D':
    Compound: HLA class I histocompatibility antigen, A-2 alpha chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2v2wd1, d2v2wd2
  • Chain 'E':
    Compound: beta-2 microglobulin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2V2W (1-9)
    • Uniprot P61769 (1-99)
    Domains in SCOPe 2.08: d2v2we2, d2v2we3
  • Chain 'F':
    Compound: hiv p17
    Species: HUMAN IMMUNODEFICIENCY VIRUS, synthetic [TaxId:12721]
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2v2wA (A:)
gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
dgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketlq
rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
fqkwaavvvpsgqeqrytchvqheglpkpltlrwep

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2v2wB (B:)
miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2v2wD (D:)
gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
dgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketlq
rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
fqkwaavvvpsgqeqrytchvqheglpkpltlrwep

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2v2wE (E:)
miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm

  • Chain 'F':
    No sequence available.