PDB entry 2v2d
View 2v2d on RCSB PDB site
Description: the a178l mutation in the c-terminal hinge of the flexible loop-6 of triosephosphate isomerase (tim) induces a more closed conformation of this hinge region in dimeric and monomeric tim
Class: isomerase
Keywords: gluconeogenesis, lipid synthesis, engineering, pentose shunt, point mutation, tim, a178l, loop6, hinge, loop-6, enzyme, isomerase, fatty acid biosynthesis, triosephosphate isomerase, glycosome, monomeric, tim-barrel, glycolysis
Deposited on
2007-06-05, released
2008-02-19
The last revision prior to the SCOPe 2.01 freeze date was dated
2011-07-13, with a file datestamp of
2011-05-31.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.204
AEROSPACI score: 0.35
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: triosephosphate isomerase glycosomal
Species: Trypanosoma brucei brucei [TaxId:5702]
Database cross-references and differences (RAF-indexed):
- Uniprot P04789 (71-241)
- conflict (13)
- conflict (16-17)
- conflict (66-70)
- conflict (72-73)
- conflict (91)
- engineered mutation (169)
Domains in SCOPe 2.01: d2v2da_ - Heterogens: PO4, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2v2dA (A:)
mskpqpiaaanwksgspdslselidlfnstsinhdvqcvvastfvhlamtkerlshpkfv
iaaqnagnadalaslkdfgvnwivlghserrwyygetneivadkvaaavasgfmviacig
etlqeresgrtavvvltqiaaiakklkkadwakvviayepvwaigtgkvltpqqaqeaha
lirswvsskigadvagelrilyggsvngknartlyqqrdvngflvggaslkpefvdiika
tq
Sequence, based on observed residues (ATOM records): (download)
>2v2dA (A:)
skpqpiaaanwksgspdslselidlfnstsinhdvqcvvastfvhlamtkerlshpkfvi
aaqnagnadalaslkdfgvnwivlghserrwyygetneivadkvaaavasgfmviacige
tlqeresgrtavvvltqiaaiakklkkadwakvviayepvwaigtgkvltpqqaqeahal
irswvsskigadvagelrilyggsvngknartlyqqrdvngflvggaslkpefvdiikat
q