PDB entry 2v2c

View 2v2c on RCSB PDB site
Description: the a178l mutation in the c-terminal hinge of the flexible loop-6 of triosephosphate isomerase (tim) induces a more closed conformation of this hinge region in dimeric and monomeric tim
Class: isomerase
Keywords: isomerase, glycosome, tim-barrel, glycolysis, engineering, pentose shunt, point mutation, tim, 2pg, a178l, loop6, hinge, loop-6, enzyme, fatty acid biosynthesis, triosephosphate isomerase, gluconeogenesis, lipid synthesis, 2-phospho glycollate
Deposited on 2007-06-05, released 2008-02-19
The last revision prior to the SCOPe 2.04 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.89 Å
R-factor: 0.142
AEROSPACI score: 0.53 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: triosephosphate isomerase glycosomal
    Species: Trypanosoma brucei brucei [TaxId:5702]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04789 (Start-249)
      • engineered mutation (177)
    Domains in SCOPe 2.04: d2v2ca_
  • Heterogens: SO4, PGA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2v2cA (A:)
mskpqpiaaanwkcngsqqslselidlfnstsinhdvqcvvastfvhlamtkerlshpkf
viaaqnaiaksgaftgevslpilkdfgvnwivlghserrayygetneivadkvaaavasg
fmviacigetlqeresgrtavvvltqiaaiakklkkadwakvviayepvwaigtgkvltp
qqaqeahalirswvsskigadvagelrilyggsvngknartlyqqrdvngflvggaslkp
efvdiikatq

    Sequence, based on observed residues (ATOM records): (download) 
    >2v2cA (A:)
skpqpiaaanwkcngsqqslselidlfnstsinhdvqcvvastfvhlamtkerlshpkfv
iaaqnaiaksgaftgevslpilkdfgvnwivlghserrayygetneivadkvaaavasgf
mviacigetlqeresgrtavvvltqiaaiakklkkadwakvviayepvwaigtgkvltpq
qaqeahalirswvsskigadvagelrilyggsvngknartlyqqrdvngflvggaslkpe
fvdiikatq