PDB entry 2uzi

View 2uzi on RCSB PDB site
Description: Crystal structure of HRAS(G12V) - anti-RAS Fv complex
Class: signaling protein/immune system
Keywords: SIGNAL TRANSDUCTION, IMMUNOGLOBULIN DOMAIN, MEMBRANE, ANTIBODY, ONCOGENE, PALMITATE, INTRABODY, DISEASE MUTATION, NUCLEOTIDE-BINDING, PROTO-ONCOGENE, CANCER THERAPY, GOLGI APPARATUS, PRENYLATION, METHYLATION, LIPOPROTEIN, GTP- BINDING, SIGNALING PROTEIN/IMMUNE SYSTEM, SIGNALING PROTEIN-IMMUNE SYSTEM complex
Deposited on 2007-04-27, released 2007-06-26
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-01-24, with a file datestamp of 2018-01-19.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'H':
    Compound: anti-ras fv heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2UZI (0-113)
    Domains in SCOPe 2.08: d2uzih_
  • Chain 'L':
    Compound: anti-ras fv light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2UZI (0-103)
    Domains in SCOPe 2.08: d2uzil_
  • Chain 'R':
    Compound: gtpase hras
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01112 (0-165)
      • engineered mutation (11)
    Domains in SCOPe 2.08: d2uzir_
  • Heterogens: ZN, GTP, MG, HOH

PDB Chain Sequences:

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2uziH (H:)
evqllesggglvqpggslrlscaasgftfstfsmnwvrqapgkglewvsyisrtsktiyy
adsvkgrftisrdnskntlylqmnslraedtavyycargrffdywgqgtlvtvs

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2uziL (L:)
iqmtqspsslsasvgdrvtitcrasqsissylnwyqqkpgeapklliysasvlqsgvpsr
fsgsgsgtdftltisslqpedfatyycqqsvmipmtfgqgtkve

  • Chain 'R':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2uziR (R:)
mteyklvvvgavgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildtag
qeeysamrdqymrtgegflcvfainntksfedihqyreqikrvkdsddvpmvlvgnkcdl
aartvesrqaqdlarsygipyietsaktrqgvedafytlvreirqh