SCOPe 2.05: Structural Classification of Proteins

PDB entry 2uz3

View 2uz3 on RCSB PDB site
Description: crystal structure of thymidine kinase with dttp from u. urealyticum
Class: transferase
Keywords: deoxyribonucleoside kinase, zinc-binding domain, feed-back inhibitor, tk1, dttp, uu-tk, kinase, transferase, ATP-binding, lasso-domain, DNA synthesis, nucleotide-binding
Deposited on 2007-04-24, released 2007-05-29
The last revision prior to the SCOPe 2.05 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.223
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: Thymidine kinase
Species: UREAPLASMA UREALYTICUM [TaxId:2130]
Database cross-references and differences (RAF-indexed):
- PDB 2UZ3
  - engineered mutation (35)
- Uniprot Q9PPP5
Domains in SCOPe 2.05: d2uz3a1, d2uz3a2
Chain 'B':
Compound: Thymidine kinase
Species: UREAPLASMA UREALYTICUM [TaxId:2130]
Database cross-references and differences (RAF-indexed):
- PDB 2UZ3
  - engineered mutation (35)
- Uniprot Q9PPP5
Domains in SCOPe 2.05: d2uz3b1, d2uz3b2
Chain 'C':
Compound: Thymidine kinase
Species: UREAPLASMA UREALYTICUM [TaxId:2130]
Database cross-references and differences (RAF-indexed):
- PDB 2UZ3
  - engineered mutation (35)
- Uniprot Q9PPP5
Domains in SCOPe 2.05: d2uz3c1, d2uz3c2
Chain 'D':
Compound: Thymidine kinase
Species: UREAPLASMA UREALYTICUM [TaxId:2130]
Database cross-references and differences (RAF-indexed):
- PDB 2UZ3
  - engineered mutation (35)
- Uniprot Q9PPP5
Domains in SCOPe 2.05: d2uz3d1, d2uz3d2
Heterogens: ZN, TTP, MG, HOH

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>2uz3A (A:)
mgsshhhhhhssglvprgshmakvnafskkigwiefitgpmfagktaelirrlhrleyad
vkylvfkpkidtrsirniqsrtgtslpsvevesapeilnyimsnsfndetkvigidevqf
fddricevanilaengfvviisgldknfkgepfgpiaklftyadkitkltaicnecgaea
thslrkidgkhadynddivkigcqefysavcrhhhkvpnrpylnsnseefikffknkkrn
kni

Sequence, based on observed residues (ATOM records): (download)

>2uz3A (A:)
igwiefitgpmfagktaelirrlhrleyadvkylvfkpkisvevesapeilnyimsnsfn
detkvigidevqffddricevanilaengfvviisgldknfkgepfgpiaklftyadkit
kltaicnecgaeathslrkidgkhadynddivkigcqefysavcrhhhkvpnrpylnsns
eefikffknk

Chain 'B':
Sequence, based on SEQRES records: (download)

>2uz3B (B:)
mgsshhhhhhssglvprgshmakvnafskkigwiefitgpmfagktaelirrlhrleyad
vkylvfkpkidtrsirniqsrtgtslpsvevesapeilnyimsnsfndetkvigidevqf
fddricevanilaengfvviisgldknfkgepfgpiaklftyadkitkltaicnecgaea
thslrkidgkhadynddivkigcqefysavcrhhhkvpnrpylnsnseefikffknkkrn
kni

Sequence, based on observed residues (ATOM records): (download)

>2uz3B (B:)
igwiefitgpmfagktaelirrlhrleyadvkylvfkpkidtrsirniqsrtgtslpsve
vesapeilnyimsnsfndetkvigidevqffddricevanilaengfvviisgldknfkg
epfgpiaklftyadkitkltaicnecgaeathslrkidgkhadynddivkigcqefysav
crhhhkvpnrpylnsnseefikffknk

Chain 'C':
Sequence, based on SEQRES records: (download)

>2uz3C (C:)
mgsshhhhhhssglvprgshmakvnafskkigwiefitgpmfagktaelirrlhrleyad
vkylvfkpkidtrsirniqsrtgtslpsvevesapeilnyimsnsfndetkvigidevqf
fddricevanilaengfvviisgldknfkgepfgpiaklftyadkitkltaicnecgaea
thslrkidgkhadynddivkigcqefysavcrhhhkvpnrpylnsnseefikffknkkrn
kni

Sequence, based on observed residues (ATOM records): (download)

>2uz3C (C:)
igwiefitgpmfagktaelirrlhrleyadvkylvfkpkslpsvevesapeilnyimsns
fndetkvigidevqffddricevanilaengfvviisgldknfkgepfgpiaklftyadk
itkltaicnecgaeathslrkidgkhadynddivkigcqefysavcrhhhkvpnrpylns
nseefikffknk

Chain 'D':
Sequence, based on SEQRES records: (download)

>2uz3D (D:)
mgsshhhhhhssglvprgshmakvnafskkigwiefitgpmfagktaelirrlhrleyad
vkylvfkpkidtrsirniqsrtgtslpsvevesapeilnyimsnsfndetkvigidevqf
fddricevanilaengfvviisgldknfkgepfgpiaklftyadkitkltaicnecgaea
thslrkidgkhadynddivkigcqefysavcrhhhkvpnrpylnsnseefikffknkkrn
kni

Sequence, based on observed residues (ATOM records): (download)

>2uz3D (D:)
igwiefitgpmfagktaelirrlhrleyadvkylvfkpkidtrsirniqsrtgtslpsve
vesapeilnyimsnsfndetkvigidevqffddricevanilaengfvviisgldknfkg
epfgpiaklftyadkitkltaicnecgaeathslrkidgkhadynddivkigcqefysav
crhhhkvpnrpylnsnseefikffknk