PDB entry 2uz3

View 2uz3 on RCSB PDB site
Description: Crystal Structure of Thymidine Kinase with dTTP from U. urealyticum
Class: transferase
Keywords: deoxyribonucleoside kinase, zinc-binding domain, feed-back inhibitor, tk1, dttp, uu-tk, kinase, transferase, ATP-binding, lasso-domain, DNA synthesis, nucleotide-binding
Deposited on 2007-04-24, released 2007-05-29
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-02-06, with a file datestamp of 2019-02-01.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thymidine kinase
    Species: UREAPLASMA UREALYTICUM [TaxId:2130]
    Database cross-references and differences (RAF-indexed):
    • PDB 2UZ3
      • engineered mutation (35)
    • Uniprot Q9PPP5
    Domains in SCOPe 2.08: d2uz3a1, d2uz3a2
  • Chain 'B':
    Compound: Thymidine kinase
    Species: UREAPLASMA UREALYTICUM [TaxId:2130]
    Database cross-references and differences (RAF-indexed):
    • PDB 2UZ3
      • engineered mutation (35)
    • Uniprot Q9PPP5
    Domains in SCOPe 2.08: d2uz3b1, d2uz3b2
  • Chain 'C':
    Compound: Thymidine kinase
    Species: UREAPLASMA UREALYTICUM [TaxId:2130]
    Database cross-references and differences (RAF-indexed):
    • PDB 2UZ3
      • engineered mutation (35)
    • Uniprot Q9PPP5
    Domains in SCOPe 2.08: d2uz3c1, d2uz3c2
  • Chain 'D':
    Compound: Thymidine kinase
    Species: UREAPLASMA UREALYTICUM [TaxId:2130]
    Database cross-references and differences (RAF-indexed):
    • PDB 2UZ3
      • engineered mutation (35)
    • Uniprot Q9PPP5
    Domains in SCOPe 2.08: d2uz3d1, d2uz3d2
  • Heterogens: ZN, TTP, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2uz3A (A:)
mgsshhhhhhssglvprgshmakvnafskkigwiefitgpmfagktaelirrlhrleyad
vkylvfkpkidtrsirniqsrtgtslpsvevesapeilnyimsnsfndetkvigidevqf
fddricevanilaengfvviisgldknfkgepfgpiaklftyadkitkltaicnecgaea
thslrkidgkhadynddivkigcqefysavcrhhhkvpnrpylnsnseefikffknkkrn
kni

    Sequence, based on observed residues (ATOM records): (download) 
    >2uz3A (A:)
igwiefitgpmfagktaelirrlhrleyadvkylvfkpkisvevesapeilnyimsnsfn
detkvigidevqffddricevanilaengfvviisgldknfkgepfgpiaklftyadkit
kltaicnecgaeathslrkidgkhadynddivkigcqefysavcrhhhkvpnrpylnsns
eefikffknk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2uz3B (B:)
mgsshhhhhhssglvprgshmakvnafskkigwiefitgpmfagktaelirrlhrleyad
vkylvfkpkidtrsirniqsrtgtslpsvevesapeilnyimsnsfndetkvigidevqf
fddricevanilaengfvviisgldknfkgepfgpiaklftyadkitkltaicnecgaea
thslrkidgkhadynddivkigcqefysavcrhhhkvpnrpylnsnseefikffknkkrn
kni

    Sequence, based on observed residues (ATOM records): (download) 
    >2uz3B (B:)
igwiefitgpmfagktaelirrlhrleyadvkylvfkpkidtrsirniqsrtgtslpsve
vesapeilnyimsnsfndetkvigidevqffddricevanilaengfvviisgldknfkg
epfgpiaklftyadkitkltaicnecgaeathslrkidgkhadynddivkigcqefysav
crhhhkvpnrpylnsnseefikffknk

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2uz3C (C:)
mgsshhhhhhssglvprgshmakvnafskkigwiefitgpmfagktaelirrlhrleyad
vkylvfkpkidtrsirniqsrtgtslpsvevesapeilnyimsnsfndetkvigidevqf
fddricevanilaengfvviisgldknfkgepfgpiaklftyadkitkltaicnecgaea
thslrkidgkhadynddivkigcqefysavcrhhhkvpnrpylnsnseefikffknkkrn
kni

    Sequence, based on observed residues (ATOM records): (download) 
    >2uz3C (C:)
igwiefitgpmfagktaelirrlhrleyadvkylvfkpkslpsvevesapeilnyimsns
fndetkvigidevqffddricevanilaengfvviisgldknfkgepfgpiaklftyadk
itkltaicnecgaeathslrkidgkhadynddivkigcqefysavcrhhhkvpnrpylns
nseefikffknk

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2uz3D (D:)
mgsshhhhhhssglvprgshmakvnafskkigwiefitgpmfagktaelirrlhrleyad
vkylvfkpkidtrsirniqsrtgtslpsvevesapeilnyimsnsfndetkvigidevqf
fddricevanilaengfvviisgldknfkgepfgpiaklftyadkitkltaicnecgaea
thslrkidgkhadynddivkigcqefysavcrhhhkvpnrpylnsnseefikffknkkrn
kni

    Sequence, based on observed residues (ATOM records): (download) 
    >2uz3D (D:)
igwiefitgpmfagktaelirrlhrleyadvkylvfkpkidtrsirniqsrtgtslpsve
vesapeilnyimsnsfndetkvigidevqffddricevanilaengfvviisgldknfkg
epfgpiaklftyadkitkltaicnecgaeathslrkidgkhadynddivkigcqefysav
crhhhkvpnrpylnsnseefikffknk