PDB entry 2uxx

View 2uxx on RCSB PDB site
Description: Human LSD1 Histone Demethylase-CoREST in complex with an FAD- tranylcypromine adduct
Class: oxidoreductase/repressor
Keywords: oxidoreductase-repressor complex, histone demethylase, oxidoreductase, nuclear protein, phosphorylation, transcription regulation, tranylcypromine, chromatin regulator, nucleosomes, transcription, host-virus interaction, chromatin demethylation, fad, lsd1, corest, repressor, depression
Deposited on 2007-03-30, released 2007-08-21
The last revision prior to the SCOPe 2.07 freeze date was dated 2013-03-27, with a file datestamp of 2013-03-22.
Experiment type: XRAY
Resolution: 2.74 Å
R-factor: 0.236
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Lysine-specific histone demethylase 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2uxxa1, d2uxxa2, d2uxxa3
  • Chain 'B':
    Compound: rest corepressor 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2uxxb1, d2uxxb2
  • Heterogens: FAJ, GOL, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2uxxA (A:)
    psgvegaafqsrlphdrmtsqeaacfpdiisgpqqtqkvflfirnrtlqlwldnpkiqlt
    featlqqleapynsdtvlvhrvhsylerhglinfgiykrikplptkktgkviiigsgvsg
    laaarqlqsfgmdvtlleardrvggrvatfrkgnyvadlgamvvtglggnpmavvskqvn
    melakikqkcplyeangqavpkekdemveqefnrlleatsylshqldfnvlnnkpvslgq
    alevviqlqekhvkdeqiehwkkivktqeelkellnkmvnlkekikelhqqykeasevkp
    prditaeflvkskhrdltalckeydelaetqgkleeklqeleanppsdvylssrdrqild
    whfanlefanatplstlslkhwdqdddfeftgshltvrngyscvpvalaegldiklntav
    rqvrytasgceviavntrstsqtfiykcdavlctlplgvlkqqppavqfvpplpewktsa
    vqrmgfgnlnkvvlcfdrvfwdpsvnlfghvgsttasrgelflfwnlykapillalvage
    aagimenisddvivgrclailkgifgssavpqpketvvsrwradpwargsysyvaagssg
    ndydlmaqpitpgpsipgapqpiprlffagehtirnypatvhgallsglreagriadqfl
    gamytl
    

    Sequence, based on observed residues (ATOM records): (download)
    >2uxxA (A:)
    psgvegaafqsrlphdrmtsqeaacfpdiisgpqqtqkvflfirnrtlqlwldnpkiqlt
    featlqqleapynsdtvlvhrvhsylerhglinfgiykrikplptkktgkviiigsgvsg
    laaarqlqsfgmdvtlleardrvggrvatfrkgnyvadlgamvvtglggnpmavvskqvn
    melakikqkcplyeangqavpkekdemveqefnrlleatsylshqldfnvlnnkpvslgq
    alevviqlqekhvkdeqiehwkkivktqeelkellnkmvnlkekikelhqqykeasevkp
    prditaeflvkskhrdltalckeydelaetqgkleeklqeleanppsdvylssrdrqild
    whfanlefanatplstlslkhwdqdddfeftgshltvrngyscvpvalaegldiklntav
    rqvrytasgceviavntrstsqtfiykcdavlctlplgvlkqqppavqfvpplpewktsa
    vqrmgfgnlnkvvlcfdrvfwdpsvnlfghvgsttasrgelflfwnlykapillalvage
    aagimenisddvivgrclailkgifgssavpqpketvvsrwradpwargsysyvaagssg
    ndydlmaqpitpgpsipgapqpiprlffagehtirnypatvhgallsglreagriadqfl
    gamyt
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >2uxxB (B:)
    mgsshhhhhhssglvprgshmasmtggqqmgrgsefgrptetvpqvkkekhstqaknrak
    rkppkgmflsqedveavsanataattvlrqldmelvsvkrqiqnikqtnsalkekldggi
    epyrlpeviqkcnarwtteeqllavqairkygrdfqaisdvignksvvqvknffvnyrrr
    fnidevlqeweaehgkeetngpsnqkpvkspdnsikmpeeedeapvldvryasas
    

    Sequence, based on observed residues (ATOM records): (download)
    >2uxxB (B:)
    rkppkgmflsqedveavsanataattvlrqldmelvsvkrqiqnikqtnsalkekldggi
    epyrlpeviqkcnarwtteeqllavqairkygrdfqaisdvignksvvqvknffvnyrrr
    fnidevlqeweaeh