PDB entry 2uxn

View 2uxn on RCSB PDB site
Description: structural basis of histone demethylation by lsd1 revealed by suicide inactivation
Class: oxidoreductase/transcription regulator
Keywords: oxidoreductase-transcription regulator complex, oxidoreductase-repressor complex, histone demethylase, fad, lsd1, corest, repressor, transcription regulation, host-virus interaction, chromatin demethylation, nuclear protein, phosphorylation, chromatin regulator, nucleosomes, transcription, oxidoreductase
Deposited on 2007-03-28, released 2007-05-29
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-31.
Experiment type: XRAY
Resolution: 2.72 Å
R-factor: 0.242
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Lysine-specific histone demethylase 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2uxna1, d2uxna2, d2uxna3
  • Chain 'B':
    Compound: rest corepressor 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2uxnb1
  • Chain 'E':
    Compound: Histone H3.1
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Heterogens: FDA, GOL, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2uxnA (A:)
    psgvegaafqsrlphdrmtsqeaacfpdiisgpqqtqkvflfirnrtlqlwldnpkiqlt
    featlqqleapynsdtvlvhrvhsylerhglinfgiykrikplptkktgkviiigsgvsg
    laaarqlqsfgmdvtlleardrvggrvatfrkgnyvadlgamvvtglggnpmavvskqvn
    melakikqkcplyeangqavpkekdemveqefnrlleatsylshqldfnvlnnkpvslgq
    alevviqlqekhvkdeqiehwkkivktqeelkellnkmvnlkekikelhqqykeasevkp
    prditaeflvkskhrdltalckeydelaetqgkleeklqeleanppsdvylssrdrqild
    whfanlefanatplstlslkhwdqdddfeftgshltvrngyscvpvalaegldiklntav
    rqvrytasgceviavntrstsqtfiykcdavlctlplgvlkqqppavqfvpplpewktsa
    vqrmgfgnlnkvvlcfdrvfwdpsvnlfghvgsttasrgelflfwnlykapillalvage
    aagimenisddvivgrclailkgifgssavpqpketvvsrwradpwargsysyvaagssg
    ndydlmaqpitpgpsipgapqpiprlffagehtirnypatvhgallsglreagriadqfl
    gamytl
    

    Sequence, based on observed residues (ATOM records): (download)
    >2uxnA (A:)
    gvegaafqsrlphdrmtsqeaacfpdiisgpqqtqkvflfirnrtlqlwldnpkiqltfe
    atlqqleapynsdtvlvhrvhsylerhglinfgiykrikplptkktgkviiigsgvsgla
    aarqlqsfgmdvtlleardrvggrvatfrkgnyvadlgamvvtglggnpmavvskqvnme
    lakikqkcplyeangqavpkekdemveqefnrlleatsylshqldfnvlnnkpvslgqal
    evviqlqekhvkdeqiehwkkivktqeelkellnkmvnlkekikelhqqykeasevkppr
    ditaeflvkskhrdltalckeydelaetqgkleeklqeleanppsdvylssrdrqildwh
    fanlefanatplstlslkhwdqdddfeftgshltvrngyscvpvalaegldiklntavrq
    vrytasgceviavntrstsqtfiykcdavlctlplgvlkqqppavqfvpplpewktsavq
    rmgfgnlnkvvlcfdrvfwdpsvnlfghvgsttasrgelflfwnlykapillalvageaa
    gimenisddvivgrclailkgifgssavpqpketvvsrwradpwargsysyvaagssgnd
    ydlmaqpitpgpsipgapqpiprlffagehtirnypatvhgallsglreagriadqflga
    mytl
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >2uxnB (B:)
    mgsshhhhhhssglvprgshmasmtggqqmgrgsefgrptetvpqvkkekhstqaknrak
    rkppkgmflsqedveavsanataattvlrqldmelvsvkrqiqnikqtnsalkekldggi
    epyrlpeviqkcnarwtteeqllavqairkygrdfqaisdvignksvvqvknffvnyrrr
    fnidevlqeweaehgkeetngpsnqkpvkspdnsikmpeeedeapvldvryasas
    

    Sequence, based on observed residues (ATOM records): (download)
    >2uxnB (B:)
    rkppkgmflsqedveavsanataattvlrqldmelvsvkrqiqnikqtnsalkekldggi
    epyrlpeviqkcnarwtteeqllavqairkygrdfqaisdvignksvvqvknffvnyrrr
    fnidevlqeweae
    

  • Chain 'E':
    No sequence available.