PDB entry 2uwo
View 2uwo on RCSB PDB site
Description: selective and dual action orally active inhibitors of thrombin and factor xa
Class: hydrolase
Keywords: target hopping, serine protease, egf-like domain, polymorphism, glycoprotein, hydroxylation, calcium, zymogen, complex, protease, hydrolase, blood coagulation, gamma- carboxyglutamic acid, cleavage on pair of basic residues
Deposited on
2007-03-22, released
2007-05-08
The last revision prior to the SCOPe 2.07 freeze date was dated
2009-02-24, with a file datestamp of
2009-03-01.
Experiment type: XRAY
Resolution: 1.75 Å
R-factor: 0.202
AEROSPACI score: 0.52
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: coagulation factor x
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d2uwoa_ - Chain 'B':
Compound: coagulation factor x
Species: Homo sapiens [TaxId:9606]
Domains in SCOPe 2.07: d2uwob_ - Heterogens: 701, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2uwoA (A:)
ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
tqktgivsgfgrthekgrqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqeda
cqgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmktrglpka
kshapevitssplk
Sequence, based on observed residues (ATOM records): (download)
>2uwoA (A:)
ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
qegeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlmtq
ktgivsgfgrthekgrqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqedacq
gdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmkt
- Chain 'B':
Sequence, based on SEQRES records: (download)
>2uwoB (B:)
eemkkghlerecmeetcsyeearevfedsdktnefwnkykdgdqcetspcqnqgkckdgl
geytctclegfegkncelftrklcsldngdcdqfcheeqnsvvcscargytladngkaci
ptgpypcgkqtler
Sequence, based on observed residues (ATOM records): (download)
>2uwoB (B:)
rklcsldngdcdqfcheeqnsvvcscargytladngkaciptgpypcgkqtl