PDB entry 2uwo

View 2uwo on RCSB PDB site
Description: selective and dual action orally active inhibitors of thrombin and factor xa
Class: hydrolase
Keywords: target hopping, serine protease, egf-like domain, polymorphism, glycoprotein, hydroxylation, calcium, zymogen, complex, protease, hydrolase, blood coagulation, gamma-carboxyglutamic acid, cleavage on pair of basic residues
Deposited on 2007-03-22, released 2007-05-08
The last revision prior to the SCOP 1.75 freeze date was dated 2007-05-08, with a file datestamp of 2007-06-28.
Experiment type: XRAY
Resolution: 1.75 Å
R-factor: 0.202
AEROSPACI score: 0.66 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: coagulation factor x
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d2uwoa1
  • Chain 'B':
    Compound: coagulation factor x
    Species: HOMO SAPIENS
    Domains in SCOP 1.75: d2uwob1
  • Heterogens: 701, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2uwoA (A:)
    ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
    qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
    tqktgivsgfgrthekgrqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqeda
    cqgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmktrglpka
    kshapevitssplk
    

    Sequence, based on observed residues (ATOM records): (download)
    >2uwoA (A:)
    ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
    qegeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlmtq
    ktgivsgfgrthekgrqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqedacq
    gdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmkt
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >2uwoB (B:)
    eemkkghlerecmeetcsyeearevfedsdktnefwnkykdgdqcetspcqnqgkckdgl
    geytctclegfegkncelftrklcsldngdcdqfcheeqnsvvcscargytladngkaci
    ptgpypcgkqtler
    

    Sequence, based on observed residues (ATOM records): (download)
    >2uwoB (B:)
    rklcsldngdcdqfcheeqnsvvcscargytladngkaciptgpypcgkqtl