PDB entry 2uwl

View 2uwl on RCSB PDB site
Description: selective and dual action orally active inhibitors of thrombin and factor xa
Class: hydrolase
Keywords: target hopping, serine protease, egf-like domain, polymorphism, glycoprotein, hydroxylation, calcium, zymogen, complex, protease, hydrolase, blood coagulation, gamma- carboxyglutamic acid, cleavage on pair of basic residues
Deposited on 2007-03-22, released 2007-04-24
The last revision prior to the SCOPe 2.01 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.196
AEROSPACI score: 0.46 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: coagulation factor x
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d2uwla_
  • Chain 'B':
    Compound: coagulation factor x
    Species: Homo sapiens [TaxId:9606]
    Domains in SCOPe 2.01: d2uwlb1
  • Heterogens: 895, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2uwlA (A:)
    ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
    qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
    tqktgivsgfgrthekgrqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqeda
    cqgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmktrglpka
    kshapevitssplk
    

    Sequence, based on observed residues (ATOM records): (download)
    >2uwlA (A:)
    ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
    qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
    tqktgivsgfgrthekgrqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqeda
    cqgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmkt
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >2uwlB (B:)
    eemkkghlerecmeetcsyeearevfedsdktnefwnkykdgdqcetspcqnqgkckdgl
    geytctclegfegkncelftrklcsldngdcdqfcheeqnsvvcscargytladngkaci
    ptgpypcgkqtler
    

    Sequence, based on observed residues (ATOM records): (download)
    >2uwlB (B:)
    rklcsldngdcdqfcheeqnsvvcscargytladngkaciptgpypcgkqtl