PDB entry 2uwe

View 2uwe on RCSB PDB site
Description: large cdr3a loop alteration as a function of MHC mutation
Class: immune system
Keywords: host-virus interaction, pyrrolidone carboxylic acid, glycoprotein, transmembrane, immune system, MHC I, membrane, receptor, class I MHC, hypothetical protein, immunoglobulin domain, immunoglobulin, immune response, tcr-pmhc complex, t cell signaling, disease mutation
Deposited on 2007-03-20, released 2007-09-25
The last revision prior to the SCOPe 2.05 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-31.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.243
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: HLA class I histocompatibility antigen, A-2 alpha chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01892 (0-274)
      • engineered mutation (162)
    Domains in SCOPe 2.05: d2uwea1, d2uwea2
  • Chain 'B':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2UWE (0-0)
    • Uniprot P61769 (1-99)
    Domains in SCOPe 2.05: d2uweb_
  • Chain 'C':
    Compound: uncharacterized protein c15orf24
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: ahiii tcr alpha chain
    Species: MUS MUSCULUS [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 2UWE (0-193)
    Domains in SCOPe 2.05: d2uwee1, d2uwee2
  • Chain 'F':
    Compound: ahiii tcr beta chain
    Species: MUS MUSCULUS [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 2UWE (Start-237)
    Domains in SCOPe 2.05: d2uwef1, d2uwef2
  • Chain 'H':
    Compound: HLA class I histocompatibility antigen, A-2 alpha chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01892 (0-274)
      • engineered mutation (162)
    Domains in SCOPe 2.05: d2uweh1, d2uweh2
  • Chain 'I':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2UWE (0-0)
    • Uniprot P61769 (1-99)
    Domains in SCOPe 2.05: d2uwei_
  • Chain 'J':
    Compound: uncharacterized protein c15orf24
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'L':
    Compound: ahiii tcr alpha chain
    Species: MUS MUSCULUS [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 2UWE (0-193)
    Domains in SCOPe 2.05: d2uwel1, d2uwel2
  • Chain 'M':
    Compound: ahiii tcr beta chain
    Species: MUS MUSCULUS [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 2UWE (Start-237)
    Domains in SCOPe 2.05: d2uwem1, d2uwem2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2uweA (A:)
    gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
    dgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
    kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegacvewlrrylengketlq
    rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
    fqkwaavvvpsgqeqrytchvqheglpkpltlrwe
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2uweB (B:)
    miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
    wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'C':
    No sequence available.

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2uweE (E:)
    mdsvtqteglvtlteglpvmlnctyqstyspflfwyvqhlneapklllksftdnkrpehq
    gfhatlhkssssfhlqkssaqlsdsalyycalflasssfsklvfgqgtslsvvpniqnpe
    pavyqlkdprsqdstlclftdfdsqinvpktmesgtfitdktvldmkamdsksngaiaws
    nqtsftcqdifket
    

  • Chain 'F':
    Sequence, based on SEQRES records: (download)
    >2uweF (F:)
    meaavtqsprskvavtggkvtlschqtnnhdymywyrqdtghglrlihysyvadstekgd
    ipdgykasrpsqenfslilelaslsqtavyfcassdwvsyeqyfgpgtrltvledlrnvt
    ppkvslfepskaeiankqkatlvclargffpdhvelswwvngkevhsgvstdpqaykesn
    ysyalssrlrvsatfwhnprnhfrcqvqfhglseedkwpegspkpvtqnisaeawgra
    

    Sequence, based on observed residues (ATOM records): (download)
    >2uweF (F:)
    eaavtqsprskvavtggkvtlschqtnnhdymywyrqdtghglrlihysyvadstekgdi
    pdgykasrpsqenfslilelaslsqtavyfcassdwvsyeqyfgpgtrltvledlrnvtp
    pkvslfepskaeiankqkatlvclargffpdhvelswwvngkevhsgvstdpqaykesny
    syalssrlrvsatfwhnprnhfrcqvqfhglseedkwpegspkpvtqnisaeawgra
    

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2uweH (H:)
    gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
    dgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
    kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegacvewlrrylengketlq
    rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
    fqkwaavvvpsgqeqrytchvqheglpkpltlrwe
    

  • Chain 'I':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2uweI (I:)
    miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
    wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'J':
    No sequence available.

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2uweL (L:)
    mdsvtqteglvtlteglpvmlnctyqstyspflfwyvqhlneapklllksftdnkrpehq
    gfhatlhkssssfhlqkssaqlsdsalyycalflasssfsklvfgqgtslsvvpniqnpe
    pavyqlkdprsqdstlclftdfdsqinvpktmesgtfitdktvldmkamdsksngaiaws
    nqtsftcqdifket
    

  • Chain 'M':
    Sequence, based on SEQRES records: (download)
    >2uweM (M:)
    meaavtqsprskvavtggkvtlschqtnnhdymywyrqdtghglrlihysyvadstekgd
    ipdgykasrpsqenfslilelaslsqtavyfcassdwvsyeqyfgpgtrltvledlrnvt
    ppkvslfepskaeiankqkatlvclargffpdhvelswwvngkevhsgvstdpqaykesn
    ysyalssrlrvsatfwhnprnhfrcqvqfhglseedkwpegspkpvtqnisaeawgra
    

    Sequence, based on observed residues (ATOM records): (download)
    >2uweM (M:)
    eaavtqsprskvavtggkvtlschqtnnhdymywyrqdtghglrlihysyvadstekgdi
    pdgykasrpsqenfslilelaslsqtavyfcassdwvsyeqyfgpgtrltvledlrnvtp
    pkvslfepskaeiankqkatlvclargffpdhvelswwvngkevhsgvstdpqaykesny
    syalssrlrvsatfwhnprnhfrcqvqfhglseedkwpegspkpvtqnisaeawgra