PDB entry 2uwe
View 2uwe on RCSB PDB site
Description: large cdr3a loop alteration as a function of MHC mutation
Class: immune system
Keywords: host-virus interaction, pyrrolidone carboxylic acid, glycoprotein, transmembrane, immune system, MHC I, membrane, receptor, class I MHC, hypothetical protein, immunoglobulin domain, immunoglobulin, immune response, tcr-pmhc complex, t cell signaling, disease mutation
Deposited on
2007-03-20, released
2007-09-25
The last revision prior to the SCOPe 2.02 freeze date was dated
2011-07-13, with a file datestamp of
2011-05-31.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.243
AEROSPACI score: 0.32
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: HLA class I histocompatibility antigen, A-2 alpha chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot P01892 (0-274)
- engineered mutation (162)
Domains in SCOPe 2.02: d2uwea1, d2uwea2 - Chain 'B':
Compound: Beta-2-microglobulin
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 2UWE (0-0)
- Uniprot P61769 (1-99)
Domains in SCOPe 2.02: d2uweb_ - Chain 'C':
Compound: uncharacterized protein c15orf24
Species: HOMO SAPIENS, synthetic [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Chain 'E':
Compound: ahiii tcr alpha chain
Species: MUS MUSCULUS [TaxId:10090]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.02: d2uwee1, d2uwee2 - Chain 'F':
Compound: ahiii tcr beta chain
Species: MUS MUSCULUS [TaxId:10090]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.02: d2uwef1, d2uwef2 - Chain 'H':
Compound: HLA class I histocompatibility antigen, A-2 alpha chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot P01892 (0-274)
- engineered mutation (162)
Domains in SCOPe 2.02: d2uweh1, d2uweh2 - Chain 'I':
Compound: Beta-2-microglobulin
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 2UWE (0-0)
- Uniprot P61769 (1-99)
Domains in SCOPe 2.02: d2uwei_ - Chain 'J':
Compound: uncharacterized protein c15orf24
Species: HOMO SAPIENS, synthetic [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Chain 'L':
Compound: ahiii tcr alpha chain
Species: MUS MUSCULUS [TaxId:10090]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.02: d2uwel1, d2uwel2 - Chain 'M':
Compound: ahiii tcr beta chain
Species: MUS MUSCULUS [TaxId:10090]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.02: d2uwem1, d2uwem2 - Heterogens: HOH
PDB Chain Sequences:
- Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)
>2uweA (A:)
gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
dgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegacvewlrrylengketlq
rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
fqkwaavvvpsgqeqrytchvqheglpkpltlrwe
- Chain 'B':
Sequence; same for both SEQRES and ATOM records: (download)
>2uweB (B:)
miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
- Chain 'C':
No sequence available.
- Chain 'E':
Sequence; same for both SEQRES and ATOM records: (download)
>2uweE (E:)
mdsvtqteglvtlteglpvmlnctyqstyspflfwyvqhlneapklllksftdnkrpehq
gfhatlhkssssfhlqkssaqlsdsalyycalflasssfsklvfgqgtslsvvpniqnpe
pavyqlkdprsqdstlclftdfdsqinvpktmesgtfitdktvldmkamdsksngaiaws
nqtsftcqdifket
- Chain 'F':
Sequence, based on SEQRES records: (download)
>2uweF (F:)
meaavtqsprskvavtggkvtlschqtnnhdymywyrqdtghglrlihysyvadstekgd
ipdgykasrpsqenfslilelaslsqtavyfcassdwvsyeqyfgpgtrltvledlrnvt
ppkvslfepskaeiankqkatlvclargffpdhvelswwvngkevhsgvstdpqaykesn
ysyalssrlrvsatfwhnprnhfrcqvqfhglseedkwpegspkpvtqnisaeawgra
Sequence, based on observed residues (ATOM records): (download)
>2uweF (F:)
eaavtqsprskvavtggkvtlschqtnnhdymywyrqdtghglrlihysyvadstekgdi
pdgykasrpsqenfslilelaslsqtavyfcassdwvsyeqyfgpgtrltvledlrnvtp
pkvslfepskaeiankqkatlvclargffpdhvelswwvngkevhsgvstdpqaykesny
syalssrlrvsatfwhnprnhfrcqvqfhglseedkwpegspkpvtqnisaeawgra
- Chain 'H':
Sequence; same for both SEQRES and ATOM records: (download)
>2uweH (H:)
gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
dgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegacvewlrrylengketlq
rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
fqkwaavvvpsgqeqrytchvqheglpkpltlrwe
- Chain 'I':
Sequence; same for both SEQRES and ATOM records: (download)
>2uweI (I:)
miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
- Chain 'J':
No sequence available.
- Chain 'L':
Sequence; same for both SEQRES and ATOM records: (download)
>2uweL (L:)
mdsvtqteglvtlteglpvmlnctyqstyspflfwyvqhlneapklllksftdnkrpehq
gfhatlhkssssfhlqkssaqlsdsalyycalflasssfsklvfgqgtslsvvpniqnpe
pavyqlkdprsqdstlclftdfdsqinvpktmesgtfitdktvldmkamdsksngaiaws
nqtsftcqdifket
- Chain 'M':
Sequence, based on SEQRES records: (download)
>2uweM (M:)
meaavtqsprskvavtggkvtlschqtnnhdymywyrqdtghglrlihysyvadstekgd
ipdgykasrpsqenfslilelaslsqtavyfcassdwvsyeqyfgpgtrltvledlrnvt
ppkvslfepskaeiankqkatlvclargffpdhvelswwvngkevhsgvstdpqaykesn
ysyalssrlrvsatfwhnprnhfrcqvqfhglseedkwpegspkpvtqnisaeawgra
Sequence, based on observed residues (ATOM records): (download)
>2uweM (M:)
eaavtqsprskvavtggkvtlschqtnnhdymywyrqdtghglrlihysyvadstekgdi
pdgykasrpsqenfslilelaslsqtavyfcassdwvsyeqyfgpgtrltvledlrnvtp
pkvslfepskaeiankqkatlvclargffpdhvelswwvngkevhsgvstdpqaykesny
syalssrlrvsatfwhnprnhfrcqvqfhglseedkwpegspkpvtqnisaeawgra