PDB entry 2uvx

View 2uvx on RCSB PDB site
Description: structure of pka-pkb chimera complexed with 7-azaindole
Class: transferase/inhibitor
Keywords: transferase/inhibitor, camp, kinase, myristate, transferase, lipoprotein, serine/threonine-protein kinase, transferase/inhibitor complex, nucleotide-binding, protein kinase inhibitor, ATP- binding, nuclear protein, phosphorylation
Deposited on 2007-03-15, released 2007-05-08
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.175
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cAMP-dependent protein kinase, alpha-catalytic subunit
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed):
    • PDB 2UVX
      • engineered mutation (104)
      • engineered mutation (123)
      • engineered mutation (173)
      • engineered mutation (181)
    • Uniprot P00517 (Start-350)
    Domains in SCOPe 2.06: d2uvxa_
  • Chain 'I':
    Compound: cAMP-dependent protein kinase inhibitor alpha
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Heterogens: GVH, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2uvxA (A:)
    mgnaaaakkgseqesvkeflakakedflkkwenpaqntahldqferiktlgtgsfgrvml
    vkhmetgnhyamkildkqkvvklkqiehtlnekrilqavnfpfltklefsfkdnsnlymv
    meyapggemfshlrrigrfsepharfyaaqivltfeylhsldliyrdlkpenlmidqqgy
    ikvtdfgfakrvkgrtwtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppff
    adqpiqiyekivsgkvrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfat
    tdwiaiyqrkveapfipkfkgpgdtsnfddyeeeeirvsinekcgkefsef
    

    Sequence, based on observed residues (ATOM records): (download)
    >2uvxA (A:)
    svkeflakakedflkkwenpaqntahldqferiktlgtgsfgrvmlvkhmetgnhyamki
    ldkqkvvklkqiehtlnekrilqavnfpfltklefsfkdnsnlymvmeyapggemfshlr
    rigrfsepharfyaaqivltfeylhsldliyrdlkpenlmidqqgyikvtdfgfakrvkg
    rtwtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppffadqpiqiyekivsg
    kvrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfattdwiaiyqrkveap
    fipkfkgpgdtsnfddyeeeeirvsinekcgkefsef
    

  • Chain 'I':
    No sequence available.