PDB entry 2uv2

View 2uv2 on RCSB PDB site
Description: Crystal Structure Of Human Ste20-Like Kinase Bound To 4-(4-(5- Cyclopropyl-1H-pyrazol-3-ylamino)-quinazolin-2-ylamino)-phenyl)- acetonitrile
Class: transferase
Keywords: transferase, serine/threonine-protein kinase, ATP-binding, phosphorylation, muscle development, kinase, apoptosis, germinal centre kinase, serine- threonine kinase 2, nucleotide-binding, serine-threonine-protein kinase
Deposited on 2007-03-08, released 2007-03-20
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-01-24, with a file datestamp of 2018-01-19.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ste20-like serine-threonine kinase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2UV2
      • engineered mutation (29)
      • microheterogeneity (187)
    • Uniprot Q9H2G2
    Domains in SCOPe 2.08: d2uv2a1
  • Heterogens: EDO, SCN, GVD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2uv2A (A:)
mhhhhhhssgvdlgtenlyfqsmkqyehvtrdlnpedfweiigelgdgafgkvykaqnke
tsvlaaakvidtkseeeledymveidilascdhpnivklldafyyennlwiliefcagga
vdavmlelerpltesqiqvvckqtldalnylhdnkiihrdlkagnilftldgdikladfg
vsakntrtiqrrdsfigtpywmapevvmcetskdrpydykadvwslgitliemaeiepph
helnpmrvllkiaksepptlaqpsrwssnfkdflkkcleknvdarwttsqllqhpfvtvd
snkpireliaeakaevteevedgke

    Sequence, based on observed residues (ATOM records): (download) 
    >2uv2A (A:)
yehvtrdlnpedfweiigelgdfgkvykaqnketsvlaaakvidtkseeeledymveidi
lascdhpnivklldafyyennlwiliefcaggavdavmlelerpltesqiqvvckqtlda
lnylhdnkiihrdlkagnilftldgdikladfgvsakntrtiqrrdsfigtpywmapevv
mcetskdrpydykadvwslgitliemaeiepphhelnpmrvllkiaksepptlaqpsrws
snfkdflkkcleknvdarwttsqllqhpfvtvdsnkpireliaeak