PDB entry 2rma
View 2rma on RCSB PDB site
Description: Crystal structures of cyclophilin A complexed with cyclosporin A and N-methyl-4-[(E)-2-butenyl]-4,4-dimethylthreonine cyclosporin A
Class: isomerase/immunosuppressant
Keywords: isomerase-immunosuppressant complex, cyclophilin-cyclosporin complex, cyclosporin a, immunosuppressant, cyclophilin
Deposited on
1994-01-07, released
1995-02-07
The last revision prior to the SCOPe 2.08 freeze date was dated
2017-11-01, with a file datestamp of
2017-10-27.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.28
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: peptidyl-prolyl cis-trans isomerase
Species: Homo sapiens [TaxId:9606]
Gene: CYCLOPHILIN A
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d2rmaa_ - Chain 'B':
Compound: cyclosporin a
Species: Tolypocladium inflatum, synthetic [TaxId:29910]
Database cross-references and differences (RAF-indexed):
- Chain 'C':
Compound: peptidyl-prolyl cis-trans isomerase
Species: Homo sapiens [TaxId:9606]
Gene: CYCLOPHILIN A
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d2rmac_ - Chain 'D':
Compound: cyclosporin a
Species: Tolypocladium inflatum, synthetic [TaxId:29910]
Database cross-references and differences (RAF-indexed):
- Chain 'E':
Compound: peptidyl-prolyl cis-trans isomerase
Species: Homo sapiens [TaxId:9606]
Gene: CYCLOPHILIN A
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d2rmae_ - Chain 'F':
Compound: cyclosporin a
Species: Tolypocladium inflatum, synthetic [TaxId:29910]
Database cross-references and differences (RAF-indexed):
- Chain 'G':
Compound: peptidyl-prolyl cis-trans isomerase
Species: Homo sapiens [TaxId:9606]
Gene: CYCLOPHILIN A
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d2rmag_ - Chain 'H':
Compound: cyclosporin a
Species: Tolypocladium inflatum, synthetic [TaxId:29910]
Database cross-references and differences (RAF-indexed):
- Chain 'I':
Compound: peptidyl-prolyl cis-trans isomerase
Species: Homo sapiens [TaxId:9606]
Gene: CYCLOPHILIN A
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d2rmai_ - Chain 'J':
Compound: cyclosporin a
Species: Tolypocladium inflatum, synthetic [TaxId:29910]
Database cross-references and differences (RAF-indexed):
- Chain 'K':
Compound: peptidyl-prolyl cis-trans isomerase
Species: Homo sapiens [TaxId:9606]
Gene: CYCLOPHILIN A
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d2rmak_ - Chain 'L':
Compound: cyclosporin a
Species: Tolypocladium inflatum, synthetic [TaxId:29910]
Database cross-references and differences (RAF-indexed):
- Chain 'M':
Compound: peptidyl-prolyl cis-trans isomerase
Species: Homo sapiens [TaxId:9606]
Gene: CYCLOPHILIN A
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d2rmam_ - Chain 'N':
Compound: cyclosporin a
Species: Tolypocladium inflatum, synthetic [TaxId:29910]
Database cross-references and differences (RAF-indexed):
- Chain 'O':
Compound: peptidyl-prolyl cis-trans isomerase
Species: Homo sapiens [TaxId:9606]
Gene: CYCLOPHILIN A
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d2rmao_ - Chain 'P':
Compound: cyclosporin a
Species: Tolypocladium inflatum, synthetic [TaxId:29910]
Database cross-references and differences (RAF-indexed):
- Chain 'Q':
Compound: peptidyl-prolyl cis-trans isomerase
Species: Homo sapiens [TaxId:9606]
Gene: CYCLOPHILIN A
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d2rmaq_ - Chain 'R':
Compound: cyclosporin a
Species: Tolypocladium inflatum, synthetic [TaxId:29910]
Database cross-references and differences (RAF-indexed):
- Chain 'S':
Compound: peptidyl-prolyl cis-trans isomerase
Species: Homo sapiens [TaxId:9606]
Gene: CYCLOPHILIN A
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d2rmas_ - Chain 'T':
Compound: cyclosporin a
Species: Tolypocladium inflatum, synthetic [TaxId:29910]
Database cross-references and differences (RAF-indexed):
- Heterogens: HOH
PDB Chain Sequences:
- Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)
>2rmaA (A:)
mvnptvffdiavdgeplgrvsfelfadkvpktaenfralstgekgfgykgscfhriipgf
mcqggdftrhngtggksiygekfedenfilkhtgpgilsmanagpntngsqffictakte
wldgkhvvfgkvkegmniveamerfgsrngktskkitiadcgqle
- Chain 'B':
No sequence available.
- Chain 'C':
Sequence; same for both SEQRES and ATOM records: (download)
>2rmaC (C:)
mvnptvffdiavdgeplgrvsfelfadkvpktaenfralstgekgfgykgscfhriipgf
mcqggdftrhngtggksiygekfedenfilkhtgpgilsmanagpntngsqffictakte
wldgkhvvfgkvkegmniveamerfgsrngktskkitiadcgqle
- Chain 'D':
No sequence available.
- Chain 'E':
Sequence; same for both SEQRES and ATOM records: (download)
>2rmaE (E:)
mvnptvffdiavdgeplgrvsfelfadkvpktaenfralstgekgfgykgscfhriipgf
mcqggdftrhngtggksiygekfedenfilkhtgpgilsmanagpntngsqffictakte
wldgkhvvfgkvkegmniveamerfgsrngktskkitiadcgqle
- Chain 'F':
No sequence available.
- Chain 'G':
Sequence; same for both SEQRES and ATOM records: (download)
>2rmaG (G:)
mvnptvffdiavdgeplgrvsfelfadkvpktaenfralstgekgfgykgscfhriipgf
mcqggdftrhngtggksiygekfedenfilkhtgpgilsmanagpntngsqffictakte
wldgkhvvfgkvkegmniveamerfgsrngktskkitiadcgqle
- Chain 'H':
No sequence available.
- Chain 'I':
Sequence; same for both SEQRES and ATOM records: (download)
>2rmaI (I:)
mvnptvffdiavdgeplgrvsfelfadkvpktaenfralstgekgfgykgscfhriipgf
mcqggdftrhngtggksiygekfedenfilkhtgpgilsmanagpntngsqffictakte
wldgkhvvfgkvkegmniveamerfgsrngktskkitiadcgqle
- Chain 'J':
No sequence available.
- Chain 'K':
Sequence; same for both SEQRES and ATOM records: (download)
>2rmaK (K:)
mvnptvffdiavdgeplgrvsfelfadkvpktaenfralstgekgfgykgscfhriipgf
mcqggdftrhngtggksiygekfedenfilkhtgpgilsmanagpntngsqffictakte
wldgkhvvfgkvkegmniveamerfgsrngktskkitiadcgqle
- Chain 'L':
No sequence available.
- Chain 'M':
Sequence; same for both SEQRES and ATOM records: (download)
>2rmaM (M:)
mvnptvffdiavdgeplgrvsfelfadkvpktaenfralstgekgfgykgscfhriipgf
mcqggdftrhngtggksiygekfedenfilkhtgpgilsmanagpntngsqffictakte
wldgkhvvfgkvkegmniveamerfgsrngktskkitiadcgqle
- Chain 'N':
No sequence available.
- Chain 'O':
Sequence; same for both SEQRES and ATOM records: (download)
>2rmaO (O:)
mvnptvffdiavdgeplgrvsfelfadkvpktaenfralstgekgfgykgscfhriipgf
mcqggdftrhngtggksiygekfedenfilkhtgpgilsmanagpntngsqffictakte
wldgkhvvfgkvkegmniveamerfgsrngktskkitiadcgqle
- Chain 'P':
No sequence available.
- Chain 'Q':
Sequence; same for both SEQRES and ATOM records: (download)
>2rmaQ (Q:)
mvnptvffdiavdgeplgrvsfelfadkvpktaenfralstgekgfgykgscfhriipgf
mcqggdftrhngtggksiygekfedenfilkhtgpgilsmanagpntngsqffictakte
wldgkhvvfgkvkegmniveamerfgsrngktskkitiadcgqle
- Chain 'R':
No sequence available.
- Chain 'S':
Sequence; same for both SEQRES and ATOM records: (download)
>2rmaS (S:)
mvnptvffdiavdgeplgrvsfelfadkvpktaenfralstgekgfgykgscfhriipgf
mcqggdftrhngtggksiygekfedenfilkhtgpgilsmanagpntngsqffictakte
wldgkhvvfgkvkegmniveamerfgsrngktskkitiadcgqle
- Chain 'T':
No sequence available.