PDB entry 2rio

View 2rio on RCSB PDB site
Description: Structure of the dual enzyme Ire1 reveals the basis for catalysis and regulation of non-conventional splicing
Class: hydrolase, transferase
Keywords: Protein-nucleotide complex, ATP-binding, Endoplasmic reticulum, Glycoprotein, Hydrolase, Kinase, Magnesium, Membrane, Metal-binding, Multifunctional enzyme, Nucleotide-binding, Phosphorylation, Serine/threonine-protein kinase, Transcription, Transcription regulation, Transferase, Transmembrane, Unfolded protein response
Deposited on 2007-10-12, released 2008-01-29
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.224
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine/threonine-protein kinase/endoribonuclease IRE1
    Species: Saccharomyces cerevisiae [TaxId:4932]
    Gene: IRE1, ERN1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d2rioa_
  • Chain 'B':
    Compound: Serine/threonine-protein kinase/endoribonuclease IRE1
    Species: Saccharomyces cerevisiae [TaxId:4932]
    Gene: IRE1, ERN1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d2riob_
  • Heterogens: MG, SR, ADP

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2rioA (A:)
srianipnfeqslknlvvsekilgygssgtvvfqgsfqgrpvavkrmlidfcdialmeik
lltesddhpnviryycsettdrflyialelcnlnlqdlvesknvsdenlklqkeynpisl
lrqiasgvahlhslkiihrdlkpqnilvstssrftadqqtgaenlrilisdfglckklds
gqssfrtnlnnpsgtsgwrapelleesnnlqtkrrltrsidifsmgcvfyyilskgkhpf
gdkysresniirgifsldemkclhdrsliaeatdlisqmidhdplkrptamkvlrhplfw
pkskklefllkvsdrleienrdppsallmkfdagsdfvipsgdwtvkfdktfmdnleryr
kyhssklmdllralrnkyhhfmdlpediaelmgpvpdgfydyftkrfpnlligvymivke
nlsddqilreflys

    Sequence, based on observed residues (ATOM records): (download) 
    >2rioA (A:)
nfeqslknlvvsekilgygssgtvvfqgsfqgrpvavkrmlidfcdialmeiklltesdd
hpnviryycsettdrflyialelcnlnlqdlveskynpisllrqiasgvahlhslkiihr
dlkpqnilvstssrftadqqtgaenlrilisdfglckkldstsgwrapelleesnnlqtk
rrltrsidifsmgcvfyyilskgkhpfgdkysresniirgifsldemkclhdrsliaeat
dlisqmidhdplkrptamkvlrhplfwpkskklefllkvsdrleienrdppsallmkfda
gsdfvipsgdwtvkfdktfmdrkyhssklmdllralrnkyhhfmdlpediaelmgpvpdg
fydyftkrfpnlligvymivkenlsddqilreflys

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2rioB (B:)
srianipnfeqslknlvvsekilgygssgtvvfqgsfqgrpvavkrmlidfcdialmeik
lltesddhpnviryycsettdrflyialelcnlnlqdlvesknvsdenlklqkeynpisl
lrqiasgvahlhslkiihrdlkpqnilvstssrftadqqtgaenlrilisdfglckklds
gqssfrtnlnnpsgtsgwrapelleesnnlqtkrrltrsidifsmgcvfyyilskgkhpf
gdkysresniirgifsldemkclhdrsliaeatdlisqmidhdplkrptamkvlrhplfw
pkskklefllkvsdrleienrdppsallmkfdagsdfvipsgdwtvkfdktfmdnleryr
kyhssklmdllralrnkyhhfmdlpediaelmgpvpdgfydyftkrfpnlligvymivke
nlsddqilreflys

    Sequence, based on observed residues (ATOM records): (download) 
    >2rioB (B:)
nfeqslknlvvsekilgygssgtvvfqgsfqgrpvavkrmlidfcdialmeiklltesdd
hpnviryycsettdrflyialelcnlnlqdlvesynpisllrqiasgvahlhslkiihrd
lkpqnilvstssrftadqqtgaenlrilisdfglckkldstsgwrapelleesnnlqtkr
rltrsidifsmgcvfyyilskgkhpfgdkysresniirgifsldemkclhdrsliaeatd
lisqmidhdplkrptamkvlrhplfwpkskklefllkvsdrleienrdppsallmkfdag
sdfvipsgdwtvkfdktfmdrkyhssklmdllralrnkyhhfmdlpediaelmgpvpdgf
ydyftkrfpnlligvymivkenlsddqilreflys