PDB entry 2rhr
View 2rhr on RCSB PDB site
Description: P94L actinorhodin ketordeuctase mutant, with NADPH and Inhibitor Emodin
Class: oxidoreductase
Keywords: oxidoreductase, polyketide, actinorhodin, ketoreductase, combinatorial biosynthesis, short chain dehydrogenase/reductase
Deposited on
2007-10-09, released
2008-08-19
The last revision prior to the SCOPe 2.08 freeze date was dated
2013-11-20, with a file datestamp of
2013-11-15.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.184
AEROSPACI score: 0.27
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Actinorhodin Polyketide Ketoreductase
Species: Streptomyces coelicolor [TaxId:1902]
Gene: actIII
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d2rhra_ - Chain 'B':
Compound: Actinorhodin Polyketide Ketoreductase
Species: Streptomyces coelicolor [TaxId:1902]
Gene: actIII
Database cross-references and differences (RAF-indexed):
- Uniprot P16544 (16-276)
- expression tag (13-15)
- engineered (109)
Domains in SCOPe 2.08: d2rhrb1, d2rhrb2 - Heterogens: NDP, EMO, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2rhrA (A:)
hhhhhhssglvprgshmatqdsevalvtgatsgigleiarrlgkeglrvfvcargeeglr
ttlkelreagveadgrtcdvrsvpeiealvaavverygpvdvlvnnagrlgggataelad
elwldvvetnltgvfrvtkqvlkaggmlergtgrivniastggkqgvvhaapysaskhgv
vgftkalglelartgitvnavcpgfvetpmaasvrehysdiwevsteeafdritarvpig
ryvqpsevaemvayligpgaaavtaqalnvcgglgny
Sequence, based on observed residues (ATOM records): (download)
>2rhrA (A:)
sevalvtgatsgigleiarrlgkeglrvfvcargeeglrttlkelreagveadgrtcdvr
svpeiealvaavverygpvdvlvnnagrlgggataeladelwldvvetnltgvfrvtkqv
lkaggmlergtgrivniastggkqgvvhaapysaskhgvvgftkalglelartgitvnav
cpgfvetpmaasvrehysdiwevsteeafdritarvpigryvqpsevaemvayligpgaa
avtaqalnvcgglgny
- Chain 'B':
Sequence, based on SEQRES records: (download)
>2rhrB (B:)
hhhhhhssglvprgshmatqdsevalvtgatsgigleiarrlgkeglrvfvcargeeglr
ttlkelreagveadgrtcdvrsvpeiealvaavverygpvdvlvnnagrlgggataelad
elwldvvetnltgvfrvtkqvlkaggmlergtgrivniastggkqgvvhaapysaskhgv
vgftkalglelartgitvnavcpgfvetpmaasvrehysdiwevsteeafdritarvpig
ryvqpsevaemvayligpgaaavtaqalnvcgglgny
Sequence, based on observed residues (ATOM records): (download)
>2rhrB (B:)
gshmatqdsevalvtgatsgigleiarrlgkeglrvfvcargeeglrttlkelreagvea
dgrtcdvrsvpeiealvaavverygpvdvlvnnagrlgggataeladelwldvvetnltg
vfrvtkqvlkaggmlergtgrivniastggkqgvvhaapysaskhgvvgftkalglelar
tgitvnavcpgfvetpmaasvrehteeafdritarvpigryvqpsevaemvayligpgaa
avtaqalnvcgglgny