PDB entry 2rhc

View 2rhc on RCSB PDB site
Description: Actinorhodin ketordeuctase, actKR, with NADP+ and Inhibitor Emodin
Class: oxidoreductase
Keywords: oxidoreductase, polyketide, actinorhodin, ketoreductase, combinatorial biosynthesis, short chain dehydrogenase/reductase
Deposited on 2007-10-08, released 2008-08-19
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.186
AEROSPACI score: 0.43 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Actinorhodin Polyketide Ketoreductase
    Species: STREPTOMYCES COELICOLOR
    Gene: actIII
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d2rhca_
  • Chain 'B':
    Compound: Actinorhodin Polyketide Ketoreductase
    Species: STREPTOMYCES COELICOLOR
    Gene: actIII
    Database cross-references and differences (RAF-indexed):
    • Uniprot P16544 (16-276)
      • expression tag (9-15)
    Domains in SCOPe 2.06: d2rhcb2, d2rhcb3
  • Heterogens: NAP, EMO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2rhcA (A:)
hhhhhhssglvprgshmatqdsevalvtgatsgigleiarrlgkeglrvfvcargeeglr
ttlkelreagveadgrtcdvrsvpeiealvaavverygpvdvlvnnagrpgggataelad
elwldvvetnltgvfrvtkqvlkaggmlergtgrivniastggkqgvvhaapysaskhgv
vgftkalglelartgitvnavcpgfvetpmaasvrehysdiwevsteeafdritarvpig
ryvqpsevaemvayligpgaaavtaqalnvcgglgny

    Sequence, based on observed residues (ATOM records): (download) 
    >2rhcA (A:)
dsevalvtgatsgigleiarrlgkeglrvfvcargeeglrttlkelreagveadgrtcdv
rsvpeiealvaavverygpvdvlvnnagrpgggataeladelwldvvetnltgvfrvtkq
vlkaggmlergtgrivniastggkqgvvhaapysaskhgvvgftkalglelartgitvna
vcpgfvetpmaasvrehysdiwevsteeafdritarvpigryvqpsevaemvayligpga
aavtaqalnvcgglgny

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2rhcB (B:)
hhhhhhssglvprgshmatqdsevalvtgatsgigleiarrlgkeglrvfvcargeeglr
ttlkelreagveadgrtcdvrsvpeiealvaavverygpvdvlvnnagrpgggataelad
elwldvvetnltgvfrvtkqvlkaggmlergtgrivniastggkqgvvhaapysaskhgv
vgftkalglelartgitvnavcpgfvetpmaasvrehysdiwevsteeafdritarvpig
ryvqpsevaemvayligpgaaavtaqalnvcgglgny

    Sequence, based on observed residues (ATOM records): (download) 
    >2rhcB (B:)
lvprgshmatqdsevalvtgatsgigleiarrlgkeglrvfvcargeeglrttlkelrea
gveadgrtcdvrsvpeiealvaavverygpvdvlvnnagrpgggataeladelwldvvet
nltgvfrvtkqvlkaggmlergtgrivniastggkqgvvhaapysaskhgvvgftkalgl
elartgitvnavcpgfvetpmaasvrehysdiwevsteeafdritarvpigryvqpseva
emvayligpgaaavtaqalnvcgglgny