PDB entry 2rgn
View 2rgn on RCSB PDB site
Description: Crystal Structure of p63RhoGEF complex with Galpha-q and RhoA
Class: SIGNALING PROTEIN complex
Keywords: Heterotrimeric G-protein, small molecular weight G-protein, signaling complex, protein-protein complex, RhoGEF, RhoA, GalphaQ, Galpha-Q, p63RhoGEF, Gq, GTP-binding, Lipoprotein, Nucleotide-binding, Palmitate, Transducer, ADP-ribosylation, Cytoskeleton, Magnesium, Membrane, Methylation, Prenylation, Proto-oncogene, SIGNALING PROTEIN complex
Deposited on
2007-10-04, released
2008-01-15
The last revision prior to the SCOPe 2.08 freeze date was dated
2018-01-24, with a file datestamp of
2018-01-19.
Experiment type: XRAY
Resolution: 3.5 Å
R-factor: N/A
AEROSPACI score: 0.08
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein G(q) subunit alpha
Species: Mus musculus [TaxId:10090]
Gene: Gnaq
Database cross-references and differences (RAF-indexed):
- Uniprot P10824
- PDB 2RGN (30-End)
Domains in SCOPe 2.08: d2rgna1, d2rgna2 - Chain 'B':
Compound: Rho guanine nucleotide exchange factor 25
Species: Homo sapiens [TaxId:9606]
Gene: ARHGEF25, GEFT
Database cross-references and differences (RAF-indexed):
- Chain 'C':
Compound: transforming protein rhoa
Species: Homo sapiens [TaxId:9606]
Gene: RHOA, ARH12, ARHA, RHO12
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d2rgnc1 - Chain 'D':
Compound: Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein G(q) subunit alpha
Species: Mus musculus [TaxId:10090]
Gene: Gnaq
Database cross-references and differences (RAF-indexed):
- Uniprot P10824
- PDB 2RGN (30-End)
Domains in SCOPe 2.08: d2rgnd1, d2rgnd2 - Chain 'E':
Compound: Rho guanine nucleotide exchange factor 25
Species: Homo sapiens [TaxId:9606]
Gene: ARHGEF25, GEFT
Database cross-references and differences (RAF-indexed):
- Chain 'F':
Compound: transforming protein rhoa
Species: Homo sapiens [TaxId:9606]
Gene: RHOA, ARH12, ARHA, RHO12
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d2rgnf1 - Heterogens: ALF, MG, GDP, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2rgnA (A:)
mgctlsaedkaaverskmidrnlredgersrrelkllllgtgesgkstfikqmriihgsg
ysdedkrgftklvyqniftamqamiramdtlkipykyehnkahaqlvrevdvekvsafen
pyvdaikslwndpgiqecydrrreyqlsdstkyylndldrvadpsylptqqdvlrvrvpt
tgiieypfdlqsvifrmvdvggqrserrkwihcfenvtsimflvalseydqvlvesdnen
rmeeskalfrtiitypwfqnssvilflnkkdlleekimyshlvdyfpeydgpqrdaqaar
efilkmfvdlnpdsdkiiyshftcatdtenirfvfaavkdtilqlnlkeynlv
Sequence, based on observed residues (ATOM records): (download)
>2rgnA (A:)
rsrrelkllllgtgesgkstfikqmriihgsgysdedkrgftklvyqniftamqamiram
dtlkipykyehnkahaqlvrevdvekvsafenpyvdaikslwndpgiqecydrrreyqls
dstkyylndldrvadpsylptqqdvlrvrvpttgiieypfdlqsvifrmvdvggqrserr
kwihcfenvtsimflvalseydqvlvesdnenrmeeskalfrtiitypwfqnssvilfln
kkdlleekimyshlvdyfpeydgpqrdaqaarefilkmfvdlnpdsdkiiyshftcatdt
enirfvfaavkdtilqlnlkeynl
- Chain 'B':
No sequence available.
- Chain 'C':
Sequence, based on SEQRES records: (download)
>2rgnC (C:)
gefmaairkklvivgdgacgktcllivfskdqfpevyvptvfenyvadievdgkqvelal
wdtagqedydrlrplsypdtdvilmcfsidspdslenipekwtpevkhfcpnvpiilvgn
kkdlrndehtrrelakmkqepvkpeegrdmanrigafgymecsaktkdgvrevfematra
alqarrgkkksgclvl
Sequence, based on observed residues (ATOM records): (download)
>2rgnC (C:)
irkklvivgdgacgktcllivfskdqfpevyvptvfenyvadievdgkqvelalwdtagq
edydrlrplsypdtdvilmcfsidspdslenipekwtpevkhfcpnvpiilvgnkkdlrn
dehtrrelakmkqepvkpeegrdmanrigafgymecsaktkdgvrevfematraalq
- Chain 'D':
Sequence, based on SEQRES records: (download)
>2rgnD (D:)
mgctlsaedkaaverskmidrnlredgersrrelkllllgtgesgkstfikqmriihgsg
ysdedkrgftklvyqniftamqamiramdtlkipykyehnkahaqlvrevdvekvsafen
pyvdaikslwndpgiqecydrrreyqlsdstkyylndldrvadpsylptqqdvlrvrvpt
tgiieypfdlqsvifrmvdvggqrserrkwihcfenvtsimflvalseydqvlvesdnen
rmeeskalfrtiitypwfqnssvilflnkkdlleekimyshlvdyfpeydgpqrdaqaar
efilkmfvdlnpdsdkiiyshftcatdtenirfvfaavkdtilqlnlkeynlv
Sequence, based on observed residues (ATOM records): (download)
>2rgnD (D:)
rsrrelkllllgtgesgkstfikqmriihgsgysdedkrgftklvyqniftamqamiram
dtlkipykyehnkahaqlvrevdvekvsafenpyvdaikslwndpgiqecydrrreyqls
dstkyylndldrvadpsylptqqdvlrvrvpttgiieypfdlqsvifrmvdvggqrserr
kwihcfenvtsimflvalseydqvlvesdnenrmeeskalfrtiitypwfqnssvilfln
kkdlleekimyshlvdyfpeydgpqrdaqaarefilkmfvdlnpdsdkiiyshftcatdt
enirfvfaavkdtilqlnlkeynl
- Chain 'E':
No sequence available.
- Chain 'F':
Sequence, based on SEQRES records: (download)
>2rgnF (F:)
gefmaairkklvivgdgacgktcllivfskdqfpevyvptvfenyvadievdgkqvelal
wdtagqedydrlrplsypdtdvilmcfsidspdslenipekwtpevkhfcpnvpiilvgn
kkdlrndehtrrelakmkqepvkpeegrdmanrigafgymecsaktkdgvrevfematra
alqarrgkkksgclvl
Sequence, based on observed residues (ATOM records): (download)
>2rgnF (F:)
rkklvivgdgacgktcllivfskdqfpevyvptvfenyvadelalwdtagqedydrlrpl
sypdtdvilmcfsidspdslenipekwtpevkhfcpnvpiilvgnkkdlrndehtrrela
kmkqepvkpeegrdmanrigafgymecsaktkdgvrevfematraalq