PDB entry 2rea
View 2rea on RCSB PDB site
Description: Crystal structures of C2ALPHA-PI3 kinase PX-domain domain indicate conformational change associated with ligand binding.
Class: transferase
Keywords: PX DOMAIN, PI3K, KINASE, TRANSFERASE, PHOSPHORYLATION, NUCLEAR PROTEIN, PHOSPHOINOSITIDE, Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane, Nucleus, Polymorphism
Deposited on
2007-09-26, released
2007-11-27
The last revision prior to the SCOPe 2.08 freeze date was dated
2009-02-24, with a file datestamp of
2009-02-03.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.235
AEROSPACI score: 0.25
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide
Species: Homo sapiens [TaxId:9606]
Gene: PIK3C2A
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d2reaa1, d2reaa2 - Heterogens: HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2reaA (A:)
mdgrikevsvftyhkkynpdkhyiyvvrilregqiepsfvfrtfdefqelhnklsiifpl
wklpgfpnrmvlgrthikdvaakrkielnsylqslmnastdvaecdlvctffhgshhhhh
h
Sequence, based on observed residues (ATOM records): (download)
>2reaA (A:)
dgrikevsvftyhkkynpdkhyiyvvrilregqiepsfvfrtfdefqelhnklsiifplw
klpgfpnrmvlgrthikdvaakrkielnsylqslmnastdvaecdlvctffhgshh