PDB entry 2rd8

View 2rd8 on RCSB PDB site
Description: Human Thymidylate Synthase Stabilized in Active Conformation by R163K Mutation: Asymmetry and Reactivity of Cys195
Class: transferase
Keywords: METHYL TRANSFERASE, Methyltransferase, Nucleotide biosynthesis
Deposited on 2007-09-21, released 2008-05-27
The last revision prior to the SCOPe 2.03 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.228
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thymidylate synthase
    Species: HOMO SAPIENS
    Gene: TYMS, TS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04818
      • engineered (162)
    Domains in SCOPe 2.03: d2rd8a_
  • Chain 'B':
    Compound: Thymidylate synthase
    Species: HOMO SAPIENS
    Gene: TYMS, TS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04818
      • engineered (162)
    Domains in SCOPe 2.03: d2rd8b_
  • Heterogens: PO4, BME, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2rd8A (A:)
mpvagselprrplppaaqerdaeprpphgelqylgqiqhilrcgvrkddrtgtgtlsvfg
mqaryslrdefpllttkrvfwkgvleellwfikgstnakelsskgvkiwdangsrdflds
lgfstreegdlgpvygfqwrhfgaeyrdmesdysgqgvdqlqkvidtiktnpddrriimc
awnprdlplmalppchalcqfyvvnselscqlyqrsgdmglgvpfniasyalltymiahi
tglkpgdfihtlgdahiylnhieplkiqlqreprpfpklrilrkvekiddfkaedfqieg
ynphptikmemav

    Sequence, based on observed residues (ATOM records): (download) 
    >2rd8A (A:)
pphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvl
eellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfgae
yrdmesdysgqgvdqlqkvidtiktnpddrriimcawnprdlplmalppchalcqfyvvn
selscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhiepl
kiqlqreprpfpklrilrkvekiddfkaedfqiegynphptik

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2rd8B (B:)
mpvagselprrplppaaqerdaeprpphgelqylgqiqhilrcgvrkddrtgtgtlsvfg
mqaryslrdefpllttkrvfwkgvleellwfikgstnakelsskgvkiwdangsrdflds
lgfstreegdlgpvygfqwrhfgaeyrdmesdysgqgvdqlqkvidtiktnpddrriimc
awnprdlplmalppchalcqfyvvnselscqlyqrsgdmglgvpfniasyalltymiahi
tglkpgdfihtlgdahiylnhieplkiqlqreprpfpklrilrkvekiddfkaedfqieg
ynphptikmemav

    Sequence, based on observed residues (ATOM records): (download) 
    >2rd8B (B:)
pphgelqylgqiqhilrcgvrkrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvlee
llwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfgaeyr
dmesdysgqgvdqlqkvidtiktnpddrriimcawnprdlplmalppchalcqfyvvnse
lscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhieplki
qlqreprpfpklrilrkvekiddfkaedfqiegynphptikm