PDB entry 2rd0

View 2rd0 on RCSB PDB site
Description: Structure of a human p110alpha/p85alpha complex
Class: Transferase/Oncoprotein
Keywords: Disease mutation, Kinase, Oncogene, Transferase, Host-virus interaction, Phosphorylation, SH2 domain, SH3 domain, Transferase-Oncoprotein COMPLEX
Deposited on 2007-09-20, released 2007-12-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 3.05 Å
R-factor: 0.267
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: PIK3CA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P42336
      • expression tag (1-13)
  • Chain 'B':
    Compound: Phosphatidylinositol 3-kinase regulatory subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: PIK3R1, GRB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2rd0b_

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2rd0B (B:)
mnnnmslqdaewywgdisreevneklrdtadgtflvrdastkmhgdytltlrkggnnkli
kifhrdgkygfsdpltfssvvelinhyrneslaqynpkldvkllypvskyqqdqvvkedn
ieavgkklheyntqfqeksreydrlyeeytrtsqeiqmkrtaieafnetikifeeqcqtq
eryskeyiekfkregnekeiqrimhnydklksriseiidsrrrleedlkkqaaeyreidk
rmnsikpdliqlrktrdqylmwltqkgvrqkklnewlgn

    Sequence, based on observed residues (ATOM records): (download) 
    >2rd0B (B:)
ieavgkklheyntqfqeksreydrlyeeytrtsqeiqmkrtaieafnetikifeeqcqtq
eryskeyiiqrimhnydklksriseiidsrrrleedlkkqaaeyreidkrmnsikpdliq
lrktrdqylmwklnewlgn