PDB entry 2ra3

View 2ra3 on RCSB PDB site
Description: Human cationic trypsin complexed with bovine pancreatic trypsin inhibitor (BPTI)
Class: hydrolase/hydrolase inhibitor
Keywords: Human cationic trypsin, Serine protease, Bovine pancreatic trypsin inhibitor, BPTI, Calcium, Digestion, Disease mutation, Hydrolase, Metal-binding, Secreted, Sulfation, Zymogen, Pharmaceutical, Protease inhibitor, Serine protease inhibitor, hydrolase/hydrolase inhibitor COMPLEX
Deposited on 2007-09-14, released 2007-12-11
The last revision prior to the SCOPe 2.01 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.46 Å
R-factor: 0.154
AEROSPACI score: 0.68 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Trypsin-1
    Species: Homo sapiens [TaxId:9606]
    Gene: PRSS1, TRP1, TRY1, TRYP1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P07477 (0-223)
      • engineered (98)
      • engineered (176)
    Domains in SCOPe 2.01: d2ra3a_
  • Chain 'B':
    Compound: Trypsin-1
    Species: Homo sapiens [TaxId:9606]
    Gene: PRSS1, TRP1, TRY1, TRYP1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P07477 (0-223)
      • engineered (98)
      • engineered (176)
    Domains in SCOPe 2.01: d2ra3b_
  • Chain 'C':
    Compound: pancreatic trypsin inhibitor
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d2ra3c_
  • Chain 'I':
    Compound: pancreatic trypsin inhibitor
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d2ra3i_
  • Heterogens: CA, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2ra3A (A:)
    ivggynceensvpyqvslnsgyhfcggslineqwvvsaghcyksriqvrlgehnievleg
    neqfinaakiirhpqydrktlnndimliklssravinahvstislptappatgtkclisg
    wgntassgadypdelqcldapvlsqakceasypgkitsnmfcvgfleggkdscqgdaggp
    vvcngqlqgvvswgdgcaqknkpgvytkvynyvkwikntiaans
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2ra3B (B:)
    ivggynceensvpyqvslnsgyhfcggslineqwvvsaghcyksriqvrlgehnievleg
    neqfinaakiirhpqydrktlnndimliklssravinahvstislptappatgtkclisg
    wgntassgadypdelqcldapvlsqakceasypgkitsnmfcvgfleggkdscqgdaggp
    vvcngqlqgvvswgdgcaqknkpgvytkvynyvkwikntiaans
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >2ra3C (C:)
    rpdfcleppytgpckariiryfynakaglcqtfvyggcrakrnnfksaedcmrtcgga
    

    Sequence, based on observed residues (ATOM records): (download)
    >2ra3C (C:)
    rpdfcleppytgpckariiryfynakaglcqtfvyggcrakrnnfksaedcmrtcg
    

  • Chain 'I':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2ra3I (I:)
    rpdfcleppytgpckariiryfynakaglcqtfvyggcrakrnnfksaedcmrtcgga