PDB entry 2r8q

View 2r8q on RCSB PDB site
Description: Structure of LmjPDEB1 in complex with IBMX
Class: hydrolase
Keywords: Leishimaniasis, parasite inhibitor selectivity, cAMP phosphodiesterase, Hydrolase
Deposited on 2007-09-11, released 2007-12-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.5 Å
R-factor: 0.19
AEROSPACI score: 0.65 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Class I phosphodiesterase PDEB1
    Species: Leishmania major [TaxId:5664]
    Gene: PDEB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2r8qa_
  • Chain 'B':
    Compound: Class I phosphodiesterase PDEB1
    Species: Leishmania major [TaxId:5664]
    Gene: PDEB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2r8qb_
  • Heterogens: ZN, MG, IBM, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2r8qA (A:)
qrnsitaqrapksvkviavtpeereavmsidfggaydftspgfnlfevrekysepmdaaa
gvvynllwnsglpekfgcreqtllnfilqcrrryrrvpyhnfyhvvdvcqtlhtylytgk
aselltelecyvllvtalvhdldhmgvnnsfylktdsplgilssasgnnsvlevhhcsla
ieilsdpaadvfeglsgqdvayayralidcvlatdmakhadalsrftelatsgfekdndt
hrrlvmetlikagdvsnvtkpfetsrmwamavteefyrqgdmekekgvevlpmfdrsknn
elargqigfidfvagkffrdivgnlfhgmqwcvdtvnsnrakwqeildgrrdsirssiv

    Sequence, based on observed residues (ATOM records): (download) 
    >2r8qA (A:)
viavtpeereavmsidfggaydftspgfnlfevrekysepmdaaagvvynllwnsglpek
fgcreqtllnfilqcrrryrrvpyhnfyhvvdvcqtlhtylytgkaselltelecyvllv
talvhdldhmgvnnsfylktdsplgilssasgnnsvlevhhcslaieilsdpaadvfegl
sgqdvayayralidcvlatdmakhadalsrftelatsgfekdndthrrlvmetlikagdv
snvtkpfetsrmwamavteefyrqgdmekekgvevlpmfdrsknnelargqigfidfvag
kffrdivgnlfhgmqwcvdtvnsnrakwqeildgr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2r8qB (B:)
qrnsitaqrapksvkviavtpeereavmsidfggaydftspgfnlfevrekysepmdaaa
gvvynllwnsglpekfgcreqtllnfilqcrrryrrvpyhnfyhvvdvcqtlhtylytgk
aselltelecyvllvtalvhdldhmgvnnsfylktdsplgilssasgnnsvlevhhcsla
ieilsdpaadvfeglsgqdvayayralidcvlatdmakhadalsrftelatsgfekdndt
hrrlvmetlikagdvsnvtkpfetsrmwamavteefyrqgdmekekgvevlpmfdrsknn
elargqigfidfvagkffrdivgnlfhgmqwcvdtvnsnrakwqeildgrrdsirssiv

    Sequence, based on observed residues (ATOM records): (download) 
    >2r8qB (B:)
viavtpeereavmsidfggaydftspgfnlfevrekysepmdaaagvvynllwnsglpek
fgcreqtllnfilqcrrryrrvpyhnfyhvvdvcqtlhtylytgkaselltelecyvllv
talvhdldhmgvnnsfylktdsplgilssasgnnsvlevhhcslaieilsdpaadvfegl
sgqdvayayralidcvlatdmakhadalsrftelatsgfekdndthrrlvmetlikagdv
snvtkpfetsrmwamavteefyrqgdmekekgvevlpmfdrsknnelargqigfidfvag
kffrdivgnlfhgmqwcvdtvnsnrakwqeildgr