PDB entry 2r6n
View 2r6n on RCSB PDB site
Description: Crystal structure of a pyrrolopyrimidine inhibitor in complex with human Cathepsin K
Class: hydrolase
Keywords: covalent bond to inhibitor, Disease mutation, Glycoprotein, Hydrolase, Lysosome, Protease, Thiol protease, Zymogen
Deposited on
2007-09-06, released
2007-11-06
The last revision prior to the SCOPe 2.08 freeze date was dated
2017-10-25, with a file datestamp of
2017-10-20.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: N/A
AEROSPACI score: 0.33
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: cathepsin k
Species: Homo sapiens [TaxId:9606]
Gene: CTSK, CTSO, CTSO2
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d2r6na_ - Heterogens: CKE, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2r6nA (A:)
grapdsvdyrkkgyvtpvknqgqcgscwafssvgalegqlkkktgkllnlspqnlvdcvs
endgcgggymtnafqyvqknrgidsedaypyvgqeescmynptgkaakcrgyreipegne
kalkravarvgpvsvaidasltsfqfyskgvyydescnsdnlnhavlavgygiqkgnkhw
iiknswgenwgnkgyilmarnknnacgianlasfpkm
Sequence, based on observed residues (ATOM records): (download)
>2r6nA (A:)
rapdsvdyrkkgyvtpvknqgqcgscwafssvgalegqlkkktgkllnlspqnlvdcvse
ndgcgggymtnafqyvqknrgidsedaypyvgqeescmynptgkaakcrgyreipegnek
alkravarvgpvsvaidasltsfqfyskgvyydescnsdnlnhavlavgygiqkgnkhwi
iknswgenwgnkgyilmarnknnacgianlasfpkm