PDB entry 2r42

View 2r42 on RCSB PDB site
Description: The Biochemical and Structural Basis for feedback Inhibition of Mevalonate Kinase and Isoprenoid Metabolism
Class: transferase
Keywords: Mevalonate Kinase, Farnesyl Thiodiphosphate, ATP-binding, Cholesterol biosynthesis, Cytoplasm, Lipid synthesis, Nucleotide-binding, Peroxisome, Steroid biosynthesis, Sterol biosynthesis, Transferase
Deposited on 2007-08-30, released 2008-06-24
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.235
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Mevalonate Kinase
    Species: Rattus norvegicus
    Gene: mvk
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2r42a1, d2r42a2
  • Heterogens: MG, FPS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2r42A (A:)
mlsevllvsapgkvilhgehavvhgkvalavalnlrtflvlrpqsngkvslnlpnvgikq
vwdvatlqlldtgfleqgdvpaptleqleklkkvaglprdcvgneglsllaflylylaic
rkqrtlpsldimvwselppgaglgssaaysvcvaaalltaceevtnplkdrgsigswpee
dlksinkwayegervihgnpsgvdnsvstwggalryqqgkmsslkrlpalqilltntkvp
rstkalvagvrsrlikfpeimaplltsidaislecervlgemaaapvpeqylvleelmdm
nqhhlnalgvghasldqlcqvtaahglhskltgaggggcgitllkpglerakveaakqal
tgcgfdcwetsigapgvsmhsatsiedpvrqalgl

    Sequence, based on observed residues (ATOM records): (download) 
    >2r42A (A:)
mlsevllvsapgkvilhgehavvhgkvalavalnlrtflvlrpqsngkvslnlpnvgikq
vwdvatlqlldtgfqleklkkvaglprdcvgneglsllaflylylaicrkqrtlpsldim
vwselppgaglgssaaysvcvaaalltaceevtnplkdrgsigswpeedlksinkwayeg
ervihgnpsgvdnsvstwggalryqqgkmsslkrlpalqilltntkvprstkalvagvrs
rlikfpeimaplltsidaislecervlgemaaapvpeqylvleelmdmnqhhlnalgvgh
asldqlcqvtaahglhskltgaggggcgitllkpglerakveaakqaltgcgfdcwetsi
gapgvsmhsatsiedpvrqalgl