PDB entry 2r3v

View 2r3v on RCSB PDB site
Description: The Biochemical and Structural Basis for Feedback Inhibition of Mevalonate Kinase and Isoprenoid Metabolism
Class: transferase
Keywords: Mevalonate Kinase, Farnesyl thiodiphophate, ATP-binding, Cataract, Cholesterol biosynthesis, Cytoplasm, Disease mutation, Lipid synthesis, Nucleotide-binding, Peroxisome, Polymorphism, Steroid biosynthesis, Sterol biosynthesis, Transferase
Deposited on 2007-08-30, released 2008-06-24
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.239
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Mevalonate Kinase
    Species: HOMO SAPIENS
    Gene: mvk
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2r3va1, d2r3va2
  • Chain 'B':
    Compound: Mevalonate Kinase
    Species: HOMO SAPIENS
    Gene: mvk
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2r3vb1, d2r3vb2
  • Chain 'C':
    Compound: Mevalonate Kinase
    Species: HOMO SAPIENS
    Gene: mvk
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2r3vc1, d2r3vc2
  • Chain 'D':
    Compound: Mevalonate Kinase
    Species: HOMO SAPIENS
    Gene: mvk
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2r3vd1, d2r3vd2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2r3vA (A:)
mlsevllvsapgkvilhgehavvhgkvalavslnlrtflrlqphsngkvdlslpnigikr
awdvarlqsldtsfleqgdvttptseqveklkevaglpddcavterlavlaflylylsic
rkqralpsldivvwselppgaglgssaaysvclaaalltvceeipnplkdgdcvnrwtke
dlelinkwafqgermihgnpsgvdnavstwggalryhqgkisslkrspalqilltntkvp
rntralvagvrnrllkfpeivaplltsidaislecervlgemgeapapeqylvleelidm
nqhhlnalgvghasldqlcqvtrarglhskltgaggggcgitllkpgleqpeveatkqal
tscgfdcletsigapgvsihsatsldsrvqqaldgl

    Sequence, based on observed residues (ATOM records): (download) 
    >2r3vA (A:)
lsevllvsapgkvilhgehavvhgkvalavslnlrtflrlqphsngkvdlslpnigikra
wdvarlqsldtsflvttptseqveklkevaglpddcavterlavlaflylylsicrkqra
lpsldivvwselppgaglgssaaysvclaaalltvceeipnplkdgdcvnrwtkedleli
nkwafqgermihgnpsgvdnavstwggalryhqgkisslkrspalqilltntkvprntra
lvagvrnrllkfpeivaplltsidaislecervlgemgeapapeqylvleelidmnqhhl
nalgvghasldqlcqvtrarglhskltgaggggcgitllkpgleqpeveatkqaltscgf
dcletsigapgvsihsatsldsrvqqaldg

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2r3vB (B:)
mlsevllvsapgkvilhgehavvhgkvalavslnlrtflrlqphsngkvdlslpnigikr
awdvarlqsldtsfleqgdvttptseqveklkevaglpddcavterlavlaflylylsic
rkqralpsldivvwselppgaglgssaaysvclaaalltvceeipnplkdgdcvnrwtke
dlelinkwafqgermihgnpsgvdnavstwggalryhqgkisslkrspalqilltntkvp
rntralvagvrnrllkfpeivaplltsidaislecervlgemgeapapeqylvleelidm
nqhhlnalgvghasldqlcqvtrarglhskltgaggggcgitllkpgleqpeveatkqal
tscgfdcletsigapgvsihsatsldsrvqqaldgl

    Sequence, based on observed residues (ATOM records): (download) 
    >2r3vB (B:)
lsevllvsapgkvilhgehavvhgkvalavslnlrtflrlqphsngkvdlslpnigikra
wdvarlqsldtsfttptseqveklkevaglpddcavterlavlaflylylsicrkqralp
sldivvwselppgaglgssaaysvclaaalltvceeipnplkdgdcvnrwtkedlelink
wafqgermihgnpsgvdnavstwggalryhqgkisslkrspalqilltntkvprntralv
agvrnrllkfpeivaplltsidaislecervlgemgeapapeqylvleelidmnqhhlna
lgvghasldqlcqvtrarglhskltgaggggcgitllkpgleqpeveatkqaltscgfdc
letsigapgvsihsatsldsrvqqaldg

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2r3vC (C:)
mlsevllvsapgkvilhgehavvhgkvalavslnlrtflrlqphsngkvdlslpnigikr
awdvarlqsldtsfleqgdvttptseqveklkevaglpddcavterlavlaflylylsic
rkqralpsldivvwselppgaglgssaaysvclaaalltvceeipnplkdgdcvnrwtke
dlelinkwafqgermihgnpsgvdnavstwggalryhqgkisslkrspalqilltntkvp
rntralvagvrnrllkfpeivaplltsidaislecervlgemgeapapeqylvleelidm
nqhhlnalgvghasldqlcqvtrarglhskltgaggggcgitllkpgleqpeveatkqal
tscgfdcletsigapgvsihsatsldsrvqqaldgl

    Sequence, based on observed residues (ATOM records): (download) 
    >2r3vC (C:)
lsevllvsapgkvilhgehavvhgkvalavslnlrtflrlqphsngkvdlslpnigikra
wdvarlqsldtsflvttptseqveklkevaglpddcavterlavlaflylylsicrkqra
lpsldivvwselppgaglgssaaysvclaaalltvceeipnplkdgdcvnrwtkedleli
nkwafqgermihgnpsgvdnavstwggalryhqgkisslkrspalqilltntkvprntra
lvagvrnrllkfpeivaplltsidaislecervlgemgeapapeqylvleelidmnqhhl
nalgvghasldqlcqvtrarglhskltgaggggcgitllkpgleqpeveatkqaltscgf
dcletsigapgvsihsatsldsrvqqaldg

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2r3vD (D:)
mlsevllvsapgkvilhgehavvhgkvalavslnlrtflrlqphsngkvdlslpnigikr
awdvarlqsldtsfleqgdvttptseqveklkevaglpddcavterlavlaflylylsic
rkqralpsldivvwselppgaglgssaaysvclaaalltvceeipnplkdgdcvnrwtke
dlelinkwafqgermihgnpsgvdnavstwggalryhqgkisslkrspalqilltntkvp
rntralvagvrnrllkfpeivaplltsidaislecervlgemgeapapeqylvleelidm
nqhhlnalgvghasldqlcqvtrarglhskltgaggggcgitllkpgleqpeveatkqal
tscgfdcletsigapgvsihsatsldsrvqqaldgl

    Sequence, based on observed residues (ATOM records): (download) 
    >2r3vD (D:)
lsevllvsapgkvilhgehavvhgkvalavslnlrtflrlqphsngkvdlslpnigikra
wdvarlqsldtsflttptseqveklkevaglpddcavterlavlaflylylsicrkqral
psldivvwselppgaglgssaaysvclaaalltvceeipnplkdgdcvnrwtkedlelin
kwafqgermihgnpsgvdnavstwggalryhqgkisslkrspalqilltntkvprntral
vagvrnrllkfpeivaplltsidaislecervlgemgeapapeqylvleelidmnqhhln
algvghasldqlcqvtrarglhskltgaggggcgitllkpgleqpeveatkqaltscgfd
cletsigapgvsihsatsldsrvqqaldg