PDB entry 2qyk

View 2qyk on RCSB PDB site
Description: Crystal structure of PDE4A10 in complex with inhibitor NPV
Class: hydrolase
Keywords: PDE4 inhibitor, subfamily inhibitor selectivity, Hydrolase
Deposited on 2007-08-15, released 2008-04-08
The last revision prior to the SCOPe 2.07 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.201
AEROSPACI score: 0.43 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cyclic AMP-specific phosphodiesterase HSPDE4A10
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE4A
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9H3H2 (2-334)
      • expression tag (1)
    Domains in SCOPe 2.07: d2qyka1, d2qyka2
  • Chain 'B':
    Compound: Cyclic AMP-specific phosphodiesterase HSPDE4A10
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE4A
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9H3H2 (2-334)
      • expression tag (0-1)
    Domains in SCOPe 2.07: d2qykb1, d2qykb2
  • Heterogens: NPV, ZN, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2qykA (A:)
hmniprfgvktdqeellaqelenlnkwglnifcvsdyaggrsltcimymifqerdllkkf
ripvdtmvtymltledhyhadvayhnslhaadvlqsthvllatpaldavftdleilaalf
aaaihdvdhpgvsnqflintnselalmyndesvlenhhlavgfkllqedncdifqnlskr
qrqslrkmvidmvlatdmskhmtlladlktmvetkkvtssgvllldnysdriqvlrnmvh
cadlsnptkplelyrqwtdrimaeffqqgdrerergmeispmcdkhtasveksqvgfidy
ivhplwetwadlvhpdaqeildtlednrdwyysai

    Sequence, based on observed residues (ATOM records): (download) 
    >2qykA (A:)
mniprfgvktdqeellaqelenlnkwglnifcvsdyaggrsltcimymifqerdllkkfr
ipvdtmvtymltledhyhadvayhnslhaadvlqsthvllatpaldavftdleilaalfa
aaihdvdhpgvsnqflintnselalmyndesvlenhhlavgfkllqedncdifqnlskrq
rqslrkmvidmvlatdmskhmtlladlktmvetkkvtssgvllldnysdriqvlrnmvhc
adlsnptkplelyrqwtdrimaeffqqgdrerergmeispmcdkhtasveksqvgfidyi
vhplwetwadlvhpdaqeildtlednrdwyysai

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2qykB (B:)
hmniprfgvktdqeellaqelenlnkwglnifcvsdyaggrsltcimymifqerdllkkf
ripvdtmvtymltledhyhadvayhnslhaadvlqsthvllatpaldavftdleilaalf
aaaihdvdhpgvsnqflintnselalmyndesvlenhhlavgfkllqedncdifqnlskr
qrqslrkmvidmvlatdmskhmtlladlktmvetkkvtssgvllldnysdriqvlrnmvh
cadlsnptkplelyrqwtdrimaeffqqgdrerergmeispmcdkhtasveksqvgfidy
ivhplwetwadlvhpdaqeildtlednrdwyysai