PDB entry 2qxb

View 2qxb on RCSB PDB site
Description: Human p53 Core Domain Mutant N235K
Class: apoptosis
Keywords: p53; apoptosis; suppressor mutation; crystal structure; rescue, Activator, Anti-oncogene, Cell cycle, Disease mutation, DNA-binding, Endoplasmic reticulum, Glycoprotein, Host-virus interaction, Li-Fraumeni syndrome, Metal-binding, Nucleus, Phosphorylation, Transcription, Transcription regulation, APOPTOSIS
Deposited on 2007-08-10, released 2008-08-26
The last revision prior to the SCOPe 2.08 freeze date was dated 2013-07-31, with a file datestamp of 2013-07-26.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.21
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cellular tumor antigen p53
    Species: Homo sapiens [TaxId:9606]
    Gene: TP53, P53
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04637 (Start-194)
      • engineered mutation (140)
    Domains in SCOPe 2.08: d2qxba_
  • Chain 'B':
    Compound: Cellular tumor antigen p53
    Species: Homo sapiens [TaxId:9606]
    Gene: TP53, P53
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04637 (Start-194)
      • engineered mutation (140)
    Domains in SCOPe 2.08: d2qxbb_
  • Chain 'C':
    Compound: Cellular tumor antigen p53
    Species: Homo sapiens [TaxId:9606]
    Gene: TP53, P53
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04637 (Start-194)
      • engineered mutation (140)
    Domains in SCOPe 2.08: d2qxbc_
  • Chain 'D':
    Compound: Cellular tumor antigen p53
    Species: Homo sapiens [TaxId:9606]
    Gene: TP53, P53
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04637 (Start-194)
      • engineered mutation (140)
    Domains in SCOPe 2.08: d2qxbd_
  • Heterogens: ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2qxbA (A:)
ssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstpppg
trvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfrh
svvvpyeppevgsdcttihykymcnsscmggmnrrpiltiitledssgnllgrnsfevrv
cacpgrdrrteeenl

    Sequence, based on observed residues (ATOM records): (download) 
    >2qxbA (A:)
svpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstpppgt
rvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfrhs
vvvpyeppevgsdcttihykymcnsscmggmnrrpiltiitledssgnllgrnsfevrvc
acpgrdrrteeenl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2qxbB (B:)
ssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstpppg
trvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfrh
svvvpyeppevgsdcttihykymcnsscmggmnrrpiltiitledssgnllgrnsfevrv
cacpgrdrrteeenl

    Sequence, based on observed residues (ATOM records): (download) 
    >2qxbB (B:)
svpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstpppgt
rvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfrhs
vvvpyeppevgsdcttihykymcnsscmggmnrrpiltiitledssgnllgrnsfevrvc
acpgrdrrteeenl

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2qxbC (C:)
ssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstpppg
trvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfrh
svvvpyeppevgsdcttihykymcnsscmggmnrrpiltiitledssgnllgrnsfevrv
cacpgrdrrteeenl

    Sequence, based on observed residues (ATOM records): (download) 
    >2qxbC (C:)
svpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstpppgt
rvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfrhs
vvvpyeppevgsdcttihykymcnsscmggmnrrpiltiitledssgnllgrnsfevrvc
acpgrdrrteeenl

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2qxbD (D:)
ssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstpppg
trvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfrh
svvvpyeppevgsdcttihykymcnsscmggmnrrpiltiitledssgnllgrnsfevrv
cacpgrdrrteeenl

    Sequence, based on observed residues (ATOM records): (download) 
    >2qxbD (D:)
svpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstpppgt
rvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfrhs
vvvpyeppevgsdcttihykymcnsscmggmnrrpiltiitledssgnllgrnsfevrvc
acpgrdrrteeenl