PDB entry 2qwn

View 2qwn on RCSB PDB site
Description: Crystal structure of disulfide-bond-crosslinked complex of bovine hsc70 (1-386aa)R171C and bovine Auxilin (810-910aa)D876C in the ADP*Pi state
Class: chaperone
Keywords: chaperone-cochaperone complex, ATP-binding, Nucleotide-binding, Nucleus, Phosphorylation, Stress response, Hydrolase, Protein phosphatase, SH3-binding, CHAPERONE
Deposited on 2007-08-10, released 2007-12-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-10-25, with a file datestamp of 2017-10-20.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Heat shock cognate 71 kDa protein
    Species: Bos taurus [TaxId:9913]
    Gene: HSPA8, HSC70
    Database cross-references and differences (RAF-indexed):
    • Uniprot P19120
      • engineered (170)
    Domains in SCOPe 2.08: d2qwna1, d2qwna2
  • Chain 'B':
    Compound: Putative tyrosine-protein phosphatase auxilin
    Species: Bos taurus [TaxId:9913]
    Gene: DNAJC6
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q27974 (0-93)
      • engineered (64)
    Domains in SCOPe 2.08: d2qwnb_
  • Heterogens: PO4, NA, MG, ADP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2qwnA (A:)
mskgpavgidlgttyscvgvfqhgkveiiandqgnrttpsyvaftdterligdaaknqva
mnptntvfdakrligrrfddavvqsdmkhwpfmvvndagrpkvqveykgetksfypeevs
smvltkmkeiaeaylgktvtnavvtvpayfndsqrqatkdagtiaglnvlciineptaaa
iaygldkkvgaernvlifdlgggtfdvsiltiedgifevkstagdthlggedfdnrmvnh
fiaefkrkhkkdisenkravrrlrtacerakrtlssstqasieidslyegidfytsitra
rfeelnadlfrgtldpvekalrdakldksqihdivlvggstripkiqkllqdffngkeln
ksinpdeavaygaavqaailsgdksenvqdllll

    Sequence, based on observed residues (ATOM records): (download) 
    >2qwnA (A:)
kgpavgidlgttyscvgvfqhgkveiiandqgnrttpsyvaftdterligdaaknqvamn
ptntvfdakrligrrfddavvqsdmkhwpfmvvndagrpkvqveykgetksfypeevssm
vltkmkeiaeaylgktvtnavvtvpayfndsqrqatkdagtiaglnvlciineptaaaia
ygldkkvgaernvlifdlgggtfdvsiltiedgifevkstagdthlggedfdnrmvnhfi
aefkrkhkkdisenkravrrlrtacerakrtlssstqasieidslyegidfytsitrarf
eelnadlfrgtldpvekalrdakldksqihdivlvggstripkiqkllqdffngkelnks
inpdeavaygaavqaailsgdks

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2qwnB (B:)
mdpeklkilewiegkernirallstmhtvlwagetkwkpvgmadlvtpeqvkkvyrkavl
vvhpckatgqpyeqyakmifmelndawsefenqg