PDB entry 2qu6

View 2qu6 on RCSB PDB site
Description: Crystal structure of the VEGFR2 kinase domain in complex with a benzoxazole inhibitor
Class: transferase
Keywords: receptor tyrosine kinase, KDR, Angiogenesis, ATP-binding, Developmental protein, Differentiation, Glycoprotein, Host-virus interaction, Immunoglobulin domain, Membrane, Nucleotide-binding, Phosphorylation, Polymorphism, Transferase, Transmembrane, Tyrosine-protein kinase
Deposited on 2007-08-03, released 2007-09-25
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-08-02, with a file datestamp of 2017-07-28.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Vascular endothelial growth factor receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: KDR, FLK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P35968 (125-306)
      • engineered (2)
      • engineered (101)
      • engineered (125)
      • expression tag (307-313)
    Domains in SCOPe 2.07: d2qu6a1, d2qu6a2
  • Chain 'B':
    Compound: Vascular endothelial growth factor receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: KDR, FLK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P35968
      • engineered (101)
    Domains in SCOPe 2.07: d2qu6b_
  • Heterogens: SO4, 857, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2qu6A (A:)
ehaerlpydaskwefprdrlklgkplgrgafgqvieadafgidktatcrtvavkmlkega
thsehralmselkilihighhlnvvnllgactkpggplmvitefckfgnlstylrskrne
fvpykvapedlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvki
cdfglardiykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsfgvllweifslgas
pypgvkideefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrptfselvehlgnll
qanaqqdrhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2qu6A (A:)
aerlpydaskwefprdrlklgkplgqvieadafgidktcrtvavkmlkthsehralmsel
kilihighhlnvvnllgactkpggplmvitefckfgnlstylrskrnefvpykvapedly
kdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvkicdfgplkwmape
tifdrvytiqsdvwsfgvllweifslgaspypgvkideefcrrlkegtrmrapdyttpem
yqtmldcwhgepsqrptfselvehlgnllqanaqqdrhhhhhh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2qu6B (B:)
ehaerlpydaskwefprdrlklgkplgrgafgqvieadafgidktatcrtvavkmlkega
thsehralmselkilihighhlnvvnllgactkpggplmvitefckfgnlstylrskrne
fvpykvapedlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvki
cdfglardiykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsfgvllweifslgas
pypgvkideefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrptfselvehlgnll
qanaqqdrhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2qu6B (B:)
ydaskwefprdrlklgkplgrqvieadafgidktatcrtvavkmlkegathsehralmse
lkilihighhlnvvnllgactkpggplmvitefckfgnlstylrskrnefvpfltlehli
cysfqvakgmeflasrkcihrdlaarnillseknvvkicdflplkwmapetifdrvytiq
sdvwsfgvllweifslgaspypgvkideefcrrlkegtrmrapdyttpemyqtmldcwhg
epsqrptfselvehlgnllq