PDB entry 2qu5

View 2qu5 on RCSB PDB site
Description: Crystal structure of the VEGFR2 kinase domain in complex with a benzimidazole inhibitor
Class: transferase
Keywords: receptor tyrosinse kinase, KDR, Angiogenesis, ATP-binding, Developmental protein, Differentiation, Glycoprotein, Host-virus interaction, Immunoglobulin domain, Membrane, Nucleotide-binding, Phosphorylation, Polymorphism, Transferase, Transmembrane, Tyrosine-protein kinase
Deposited on 2007-08-03, released 2007-09-25
The last revision prior to the SCOPe 2.04 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 2.95 Å
R-factor: 0.213
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Vascular endothelial growth factor receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: KDR, FLK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P35968 (125-End)
      • engineered (2)
      • engineered (101)
      • engineered (125)
    Domains in SCOPe 2.04: d2qu5a_
  • Heterogens: 276, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2qu5A (A:)
ehaerlpydaskwefprdrlklgkplgrgafgqvieadafgidktatcrtvavkmlkega
thsehralmselkilihighhlnvvnllgactkpggplmvitefckfgnlstylrskrne
fvpykvapedlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvki
cdfglardiykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsfgvllweifslgas
pypgvkideefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrptfselvehlgnll
qanaqqdrhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2qu5A (A:)
haerlpydaskwefprdrlklgkplgrgafgqvieadafgidktatcrtvavkmlkegat
hsehralmselkilihighhlnvvnllgactkpggplmvitefckfgnlstylrskrnef
vpykvapedlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvkic
dfgladarlplkwmapetifdrvytiqsdvwsfgvllweifslgaspypgvkideefcrr
lkegtrmrapdyttpemyqtmldcwhgepsqrptfselvehlgnllqanaqq