PDB entry 2qre

View 2qre on RCSB PDB site
Description: Crystal structure of the adenylate sensor from AMP-activated protein kinase in complex with 5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranotide (ZMP)
Class: transferase
Keywords: AMPK, 5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranotide, ZMP, AICAR phosphate, ATP-binding, Kinase, Nucleotide-binding, Serine/threonine-protein kinase, Transferase, CBS domain
Deposited on 2007-07-28, released 2007-10-23
The last revision prior to the SCOPe 2.04 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 3.01 Å
R-factor: 0.239
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: SNF1-like protein kinase ssp2
    Species: Schizosaccharomyces pombe [TaxId:4896]
    Gene: ssp2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d2qrea_
  • Chain 'B':
    Compound: SPCC1919.03c protein
    Species: Schizosaccharomyces pombe [TaxId:4896]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d2qreb_
  • Chain 'C':
    Compound: SNF1-like protein kinase ssp2
    Species: Schizosaccharomyces pombe [TaxId:4896]
    Gene: ssp2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d2qrec_
  • Chain 'D':
    Compound: SPCC1919.03c protein
    Species: Schizosaccharomyces pombe [TaxId:4896]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d2qred_
  • Chain 'E':
    Compound: Protein C1556.08c
    Species: Schizosaccharomyces pombe [TaxId:4896]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q10343 (2-End)
      • expression tag (1)
    Domains in SCOPe 2.04: d2qree1, d2qree2
  • Chain 'G':
    Compound: Protein C1556.08c
    Species: Schizosaccharomyces pombe [TaxId:4896]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q10343 (2-End)
      • expression tag (1)
    Domains in SCOPe 2.04: d2qreg1, d2qreg2
  • Heterogens: AMZ, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2qreA (A:)
sqstrkksrrnkwhfgvrcrgdapeillavyralqragaqftvpkpvngkyrsdmytiks
rweiphckregkntyayielqlyevmpgcfmldvksngykdiyshpertadhgmddlkss
fpfldlcamlvcklfsa

    Sequence, based on observed residues (ATOM records): (download) 
    >2qreA (A:)
kwhfgvrcrgdapeillavyralqragaqftvpkpvnsdmytiksrweiphckregknty
ayielqlyevmpgcfmldvksngykdiyskssfpfldlcamlvcklfsa

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2qreB (B:)
mseseqysteipafltsntlqelklpkppslpphlekcilnsntaykedqsvlpnpnhvl
lnhlaaantqlgvlalsattryhrkyvttamfknfdv

    Sequence, based on observed residues (ATOM records): (download) 
    >2qreB (B:)
qysteipafltslqelklpkppslpphlekcilnsntdqsvlpnpnhvllnhlaaantql
gvlalsattryhrkyvttamfknfd

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2qreC (C:)
sqstrkksrrnkwhfgvrcrgdapeillavyralqragaqftvpkpvngkyrsdmytiks
rweiphckregkntyayielqlyevmpgcfmldvksngykdiyshpertadhgmddlkss
fpfldlcamlvcklfsa

    Sequence, based on observed residues (ATOM records): (download) 
    >2qreC (C:)
nkwhfgvrcrgdapeillavyralqragaqftvpkpvngkyrsdmytiksrweiphckre
gkntyayielqlyevmpgcfmldvksngykddlkssfpfldlcamlvcklfsa

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2qreD (D:)
mseseqysteipafltsntlqelklpkppslpphlekcilnsntaykedqsvlpnpnhvl
lnhlaaantqlgvlalsattryhrkyvttamfknfdv

    Sequence, based on observed residues (ATOM records): (download) 
    >2qreD (D:)
qysteipafltsntlqelklpkppslpphlekcilnsntaykedqsvlpnpnhvllnhla
aantqlgvlalsattryhrkyvttamfknfd

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >2qreE (E:)
amdvqetqkgalkeiqafirsrtsydvlptsfrlivfdvtlfvktslslltlnnivsapl
wdseankfaglltmadfvnvikyyyqsssfpeaiaeidkfrllglreverkigaippeti
yvhpmhslmdaclamsksrarriplidvdgetgsemivsvltqyrilkfismncketaml
rvplnqmtigtwsnlatasmetkvydvikmlaeknisavpivnsegtllnvyesvdvmhl
iqdgdysnldlsvgeallkrpanfdgvhtcratdrldgifdaikhsrvhrlfvvdenlkl
egilsladilnyiiydktttpgvpeqtdnfesav

    Sequence, based on observed residues (ATOM records): (download) 
    >2qreE (E:)
mdvqetqkgalkeiqafirsrtsydvlptsfrlivfdvtlfvktslslltlnnivsaplw
dseankfaglltmadfvnvikyyyqsssfpeaiaeidkfrllglreverkigaippetiy
vhpmhslmdaclamsksrarriplidvdgetgsemivsvltqyrilkfismncketamlr
vplnqmtigtwsnlatasmetkvydvikmlaeknisavpivnsegtllnvyesvdvmhli
qdgdysnldlsvgeallkrpanfdgvhtcratdrldgifdaikhsrvhrlfvvdenlkle
gilsladilnyiiyd

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >2qreG (G:)
amdvqetqkgalkeiqafirsrtsydvlptsfrlivfdvtlfvktslslltlnnivsapl
wdseankfaglltmadfvnvikyyyqsssfpeaiaeidkfrllglreverkigaippeti
yvhpmhslmdaclamsksrarriplidvdgetgsemivsvltqyrilkfismncketaml
rvplnqmtigtwsnlatasmetkvydvikmlaeknisavpivnsegtllnvyesvdvmhl
iqdgdysnldlsvgeallkrpanfdgvhtcratdrldgifdaikhsrvhrlfvvdenlkl
egilsladilnyiiydktttpgvpeqtdnfesav

    Sequence, based on observed residues (ATOM records): (download) 
    >2qreG (G:)
mdvqetqkgalkeiqafirsrtsydvlptsfrlivfdvtlfvktslslltlnnivsaplw
dseankfaglltmadfvnvikyyyqsssfpeaiaeidkfrllglreverkigaippetiy
vhpmhslmdaclamsksrarriplidvdgetgsemivsvltqyrilkfismncketamlr
vplnqmtigtwsnlatasmetkvydvikmlaeknisavpivnsegtllnvyesvdvmhli
qdgdysnldlsvgeallkrpanfdgvhtcratdrldgifdaikhsrvhrlfvvdenlkle
gilsladilnyiiyd