PDB entry 2qqn

View 2qqn on RCSB PDB site
Description: Neuropilin-1 b1 Domain in Complex with a VEGF-Blocking Fab
Class: signaling protein
Keywords: VEGF receptor, semaphorin receptor, Phage-Derived Antibody, Angiogenesis, Developmental protein, Differentiation, Glycoprotein, Heparan sulfate, Membrane, Neurogenesis, Proteoglycan, Secreted, Transmembrane, HORMONE, SIGNALING PROTEIN
Deposited on 2007-07-26, released 2007-11-20
The last revision prior to the SCOPe 2.05 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.162
AEROSPACI score: 0.43 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Neuropilin-1
    Species: Homo sapiens [TaxId:9606]
    Gene: NRP1, NRP, VEGF165R
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2qqna_
  • Chain 'H':
    Compound: antibody heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2QQN (0-229)
    Domains in SCOPe 2.05: d2qqnh1, d2qqnh2
  • Chain 'L':
    Compound: Antibody Light Chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2QQN (0-213)
    Domains in SCOPe 2.05: d2qqnl1, d2qqnl2
  • Heterogens: EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2qqnA (A:)
    gshmfkcmealgmesgeihsdqitassqystnwsaersrlnypengwtpgedsyrewiqv
    dlgllrfvtavgtqgaisketkkkyyvktykidvssngedwitikegnkpvlfqgntnpt
    dvvvavfpkplitrfvrikpatwetgismrfevygckit
    

    Sequence, based on observed residues (ATOM records): (download)
    >2qqnA (A:)
    kcmealgmesgeihsdqitassqystnwsaersrlnypengwtpgedsyrewiqvdlgll
    rfvtavgtqgaisketkkkyyvktykidvssngedwitikegnkpvlfqgntnptdvvva
    vfpkplitrfvrikpatwetgismrfevygckit
    

  • Chain 'H':
    Sequence, based on SEQRES records: (download)
    >2qqnH (H:)
    evqlvesggglvqpggslrlscaasgftfssyamswvrqapgkglewvsqispaggytny
    adsvkgrftisadtskntaylqmnslraedtavyycargelpyyrmskvmdvwgqgtlvt
    vssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavl
    qssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdkth
    

    Sequence, based on observed residues (ATOM records): (download)
    >2qqnH (H:)
    evqlvesggglvqpggslrlscaasgftfssyamswvrqapgkglewvsqispaggytny
    adsvkgrftisadtskntaylqmnslraedtavyycargelpyyrmskvmdvwgqgtlvt
    vssastkgpsvfplapssggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssg
    lyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdkth
    

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2qqnL (L:)
    diqmtqspsslsasvgdrvtitcrasqyfssylawyqqkpgkapklliygassrasgvps
    rfsgsgsgtdftltisslqpedfatyycqqylgspptfgqgtkveikrtvaapsvfifpp
    sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
    lskadyekhkvyacevthqglsspvtksfnrgec